(Q52849456)

8 May 2018

review article

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title

Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription. (English)

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8 May 2018

author

Ana Pombo

series ordinal

2

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8 May 2018

Robert A Beagrie

object named as

Robert A Beagrie

series ordinal

1

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language of work or name

English

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publication date

25 July 2016

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8 May 2018

published in

BioEssays

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8 May 2018

volume

38

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8 May 2018

issue

9

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8 May 2018

page(s)

881-893

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8 May 2018

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

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Locus-specific editing of histone modifications at endogenous enhancers

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Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

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Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

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Enhancer transcribed RNAs arise from hypomethylated, Tet-occupied genomic regions.

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Polycomb eviction as a new distant enhancer function.

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Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.

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Chromatin organization and global regulation of Hox gene clusters

21 January 2018

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The dynamic architecture of Hox gene clusters.

21 January 2018

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A regulatory archipelago controls Hox genes transcription in digits

21 January 2018

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A switch between topological domains underlies HoxD genes collinearity in mouse limbs

21 January 2018

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Polycomb in Transcriptional Phase Transition of Developmental Genes

21 January 2018

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Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

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Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

21 January 2018

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BET bromodomains mediate transcriptional pause release in heart failure

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Formation of the androgen receptor transcription complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Widespread transcription at neuronal activity-regulated enhancers

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

A large fraction of extragenic RNA pol II transcription sites overlap enhancers

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene

21 January 2018

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Dissecting the function of the adult β-globin downstream promoter region using an artificial zinc finger DNA-binding domain

21 January 2018

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Looping versus linking: toward a model for long-distance gene activation

21 January 2018

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The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

21 January 2018

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A facilitated tracking and transcription mechanism of long-range enhancer function

21 January 2018

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Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking

21 January 2018

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Transcription of the hypersensitive site HS2 enhancer in erythroid cells

21 January 2018

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Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Locus control region transcription plays an active role in long-range gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

The effect of distance on long-range chromatin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Going the distance: a current view of enhancer action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Dynamics of enhancer-promoter communication during differentiation-induced gene activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Topological domains in mammalian genomes identified by analysis of chromatin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Spatial partitioning of the regulatory landscape of the X-inactivation centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Predicting chromatin organization using histone marks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

eRNAs are required for p53-dependent enhancer activity and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Enhancer RNA facilitates NELF release from immediate early genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Transcription factor trapping by RNA in gene regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Nuclear stability and transcriptional directionality separate functionally distinct RNA species

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Integrator mediates the biogenesis of enhancer RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Unlinking an lncRNA from Its Associated cis Element

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Gene regulation by the act of long non-coding RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Enhancers and silencers: an integrated and simple model for their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

A unified architecture of transcriptional regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Dynamic trans-acting factor colocalization in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

An integrative analysis of TFBS-clustered regions reveals new transcriptional regulation models on the accessible chromatin landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

In pursuit of design principles of regulatory sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Understanding how cis-regulatory function is encoded in DNA sequence using massively parallel reporter assays and designed sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Decoding enhancers using massively parallel reporter assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Massively parallel functional dissection of mammalian enhancers in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Genome-wide quantitative enhancer activity maps identified by STARR-seq

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Complex effects of nucleotide variants in a mammalian cis-regulatory element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Function-based identification of mammalian enhancers using site-specific integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Chromatin position effects assayed by thousands of reporters integrated in parallel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Transcriptional activation by recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Saturation editing of genomic regions by multiplex homology-directed repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201600032

Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201600032

21 January 2018

Identifiers

DOI

10.1002/BIES.201600032

1 reference

8 May 2018

PubMed ID

27452946

1 reference

8 May 2018