(Q53272675)

12 May 2018

title

Genomic instability in chronic myeloid leukemia: targets for therapy? (English)

1 reference

12 May 2018

main subject

chronic myeloid leukemia

0 references

1 reference

N Muvarak

1

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12 May 2018

P Nagaria

series ordinal

2

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12 May 2018

F V Rassool

series ordinal

3

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12 May 2018

publication date

1 June 2012

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12 May 2018

Current hematologic malignancy reports

published in

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12 May 2018

volume

7

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12 May 2018

issue

2

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12 May 2018

page(s)

94-102

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12 May 2018

Biology of chronic myelogenous leukemia--signaling pathways of initiation and transformation

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21 January 2018

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Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors.

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21 January 2018

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Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability

21 January 2018

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The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

21 January 2018

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Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

21 January 2018

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Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

21 January 2018

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BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations

21 January 2018

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BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia

21 January 2018

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Genomic instability--an evolving hallmark of cancer

21 January 2018

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Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate.

21 January 2018

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Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

21 January 2018

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Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.

21 January 2018

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BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold

21 January 2018

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Chronic myeloid leukaemia as a model of disease evolution in human cancer

21 January 2018

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The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells

21 January 2018

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BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

21 January 2018

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Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line

21 January 2018

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

21 January 2018

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

BRCA1 regulates gene expression for orderly mitotic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

21 January 2018

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Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

The Fanconi anaemia/BRCA pathway

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

DNA double-strand break repair: from mechanistic understanding to cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Mechanisms of double-strand break repair in somatic mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Survival and induction of SOS in Escherichia coli treated with cisplatin, UV-irradiation, or mitomycin C are dependent on the function of the RecBC and RecFOR pathways of homologous recombination.

21 January 2018

1 reference

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The mechanism of human nonhomologous DNA end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Mechanism and regulation of human non-homologous DNA end-joining

21 January 2018

1 reference

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

21 January 2018

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Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells

21 January 2018

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BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair

21 January 2018

1 reference

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Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

21 January 2018

1 reference

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Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

21 January 2018

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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

BCR-ABL down-regulates the DNA repair protein DNA-PKcs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

BCR/ABL stimulates WRN to promote survival and genomic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

STI571 reduces NER activity in BCR/ABL-expressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Do reactive oxygen species play a role in myeloid leukemias?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Hemin counteracts the repression of Bcl-2 and NrF2 genes and the cell killing induced by imatinib in human Bcr-Abl(+) CML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Targeting abnormal DNA double strand break repair in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Targeting abnormal DNA repair in therapy-resistant breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-012-0119-0

21 January 2018

DNA damage and apoptosis

1 reference

12 December 2020

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.

1 reference

12 December 2020

Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins

1 reference

12 December 2020

Chromosomal characteristics of chronic and blastic phases of Ph-positive chronic myeloid leukemia

1 reference

12 December 2020

Evidence for a multistep pathogenesis of chronic myelogenous leukemia

1 reference

12 December 2020

Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis

1 reference

12 December 2020

Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia

1 reference

12 December 2020

Isochromosome 17q in Ph1-negative leukemia: a clinical, cytogenetic, and molecular study.

1 reference

12 December 2020

Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia.

1 reference

12 December 2020

Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer

1 reference

12 December 2020

Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia

1 reference

12 December 2020

Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.

1 reference

12 December 2020

A backup DNA repair pathway moves to the forefront

1 reference

12 December 2020

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

1 reference

12 December 2020

10.1007/S11899-012-0119-0

Identifiers

DOI

1 reference

12 May 2018

1 reference

12 May 2018