(Q53436494)

14 May 2018

title

Asymmetric RNA duplexes mediate RNA interference in mammalian cells. (English)

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14 May 2018

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Xiangao Sun

1

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14 May 2018

Harry A Rogoff

series ordinal

2

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14 May 2018

Chiang J Li

series ordinal

3

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14 May 2018

publication date

23 November 2008

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14 May 2018

published in

Nature Biotechnology

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14 May 2018

volume

26

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14 May 2018

page(s)

1379-1382

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14 May 2018

issue

12

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14 May 2018

https://scigraph.springernature.com/pub.10.1038/nbt.1512

exact match

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cites work

Interfering with disease: a progress report on siRNA-based therapeutics

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

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Synthetic shRNAs as potent RNAi triggers.

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Enhancement of RNAi activity by improved siRNA duplexes.

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The contributions of dsRNA structure to Dicer specificity and efficiency

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Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

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Sticky overhangs enhance siRNA-mediated gene silencing

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Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

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Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

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Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect

21 January 2018

1 reference

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

Off-target effects of siRNA specific for GFP

21 January 2018

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Activation of the interferon system by short-interfering RNAs

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Short hairpin RNA-expressing bacteria elicit RNA interference in mammals

21 January 2018

1 reference

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

Argonaute2 is the catalytic engine of mammalian RNAi

21 January 2018

1 reference

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

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siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

1 reference

Potent RNAi by short RNA triggers.

21 January 2018

1 reference

Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

1 reference

Chemical modification: the key to clinical application of RNA interference?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NBT.1512

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14 May 2018

PubMed ID

19029911

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14 May 2018