(Q53730678)

18 May 2018

title

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer. (English)

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18 May 2018

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10

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18 May 2018

Salvatore Piscuoglio

13

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18 May 2018

Rajmohan Murali

16

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18 May 2018

Jorge Reis-Filho

21

Jorge S Reis-Filho

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18 May 2018

1

Britta Weigelt

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18 May 2018

Larry Norton

15

Larry Norton

1 reference

18 May 2018

Luciano G. Martelotto

9

Luciano G Martelotto

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18 May 2018

Ino de Bruijn

3

Ino de Bruijn

1 reference

18 May 2018

Pier Selenica

12

Pier Selenica

1 reference

18 May 2018

Carol Aghajanian

14

Carol Aghajanian

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18 May 2018

author name string

Iñaki Comino-Méndez

2

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18 May 2018

Lei Tian

4

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18 May 2018

Jane L Meisel

5

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18 May 2018

Isaac García-Murillas

6

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18 May 2018

Charlotte Fribbens

7

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18 May 2018

Ros Cutts

8

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18 May 2018

Raymond S Lim

11

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18 May 2018

David M Hyman

17

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18 May 2018

Laetitia Borsu

18

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18 May 2018

Maria E Arcila

19

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18 May 2018

Jason Konner

20

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18 May 2018

Roger A Greenberg

22

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18 May 2018

Mark E Robson

23

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18 May 2018

Nicholas C Turner

24

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18 May 2018

language of work or name

English

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publication date

1 August 2017

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18 May 2018

published in

Clinical Cancer Research

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18 May 2018

volume

23

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18 May 2018

issue

21

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18 May 2018

page(s)

6708-6720

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18 May 2018

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

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Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer.

25 August 2018

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The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas.

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Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.

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Intraindividual genomic heterogeneity of high-grade serous carcinoma of the ovary and clinical utility of ascitic cancer cells for mutation profiling.

25 August 2018

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The current status of PARP inhibitors in ovarian cancer

25 August 2018

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Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples

25 August 2018

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Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

25 August 2018

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Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

25 August 2018

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The Genomic Landscape of Male Breast Cancers

25 August 2018

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Massively Parallel Sequencing-Based Clonality Analysis of Synchronous Endometrioid Endometrial and Ovarian Carcinomas

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

25 August 2018

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Advances in PARP inhibitors for the treatment of breast cancer

25 August 2018

1 reference

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Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.

25 August 2018

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Whole-genome characterization of chemoresistant ovarian cancer.

25 August 2018

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Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

25 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Oncotator: cancer variant annotation tool

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Detection of circulating tumor DNA in early- and late-stage human malignancies

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Absolute quantification of somatic DNA alterations in human cancer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

BRCA1 and BRCA2: different roles in a common pathway of genome protection

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Integrated genomic analyses of ovarian carcinoma

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Integrative genomics viewer

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Secondary mutations of BRCA1/2 and drug resistance

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

The Sequence Alignment/Map format and SAMtools

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Fast and accurate short read alignment with Burrows-Wheeler transform

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Resistance to therapy caused by intragenic deletion in BRCA2

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Cellular processing of platinum anticancer drugs

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

Extending the platinum-free interval in recurrent ovarian cancer: the role of topotecan in second-line chemotherapy.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5728372

10.1158/1078-0432.CCR-17-0544

25 August 2018

Identifiers

DOI

1 reference

18 May 2018

0 references

1 reference

18 May 2018