(Q53807960)

20 May 2018

title

Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation. (English)

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20 May 2018

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1

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20 May 2018

author name string

Mugdha V Joglekar

series ordinal

2

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20 May 2018

Anandwardhan A Hardikar

series ordinal

3

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20 May 2018

publication date

1 January 2015

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20 May 2018

published in

EXS

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20 May 2018

volume

106

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20 May 2018

page(s)

215-244

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20 May 2018

Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring

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Transcriptional mechanisms controlling miR-375 gene expression in the pancreas

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Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes.

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MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines

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Dicer is essential for mouse development

21 January 2018

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Quantitative differential expression analysis reveals miR-7 as major islet microRNA.

21 January 2018

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Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes.

21 January 2018

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MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas

21 January 2018

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Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors

21 January 2018

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Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.

21 January 2018

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Maternal protein restriction leads to pancreatic failure in offspring: role of misexpressed microRNA-375.

21 January 2018

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Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine

21 January 2018

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Neurogenin3 cooperates with Foxa2 to autoactivate its own expression.

21 January 2018

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miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

21 January 2018

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Akt and PTEN: beta-cell mass and pancreas plasticity.

21 January 2018

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Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression

21 January 2018

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Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion

21 January 2018

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Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion

21 January 2018

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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

21 January 2018

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Pancreatic beta cells require NeuroD to achieve and maintain functional maturity

21 January 2018

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MafA and MafB activity in pancreatic β cells

21 January 2018

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Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation

21 January 2018

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Clinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinoma

21 January 2018

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Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.

21 January 2018

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Development of the human pancreas from foregut to endocrine commitment.

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

New pancreas from old: microregulators of pancreas regeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3.

21 January 2018

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https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Expression of islet-specific microRNAs during human pancreatic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Insulin-promoter-factor 1 is required for pancreas development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Dicer1 is required to repress neuronal fate during endocrine cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Circulating miRNA profiles in patients with metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Pancreas-enriched miRNA refines endocrine cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Regulation of pancreatic microRNA-7 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Foxa2 is required for the differentiation of pancreatic alpha-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Epithelial-mesenchymal transitions: insights from development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA expression is required for pancreatic islet cell genesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miRiad roles for the miR-17-92 cluster in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Circulating microRNAs as stable blood-based markers for cancer detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Ectopic Ptf1a expression in murine ESCs potentiates endocrine differentiation and models pancreas development in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Regulation of Human PAX6 Expression by miR-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miR-19 is a key oncogenic component of mir-17-92

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Serum circulating microRNA profiling for identification of potential type 2 diabetes and obesity biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Beta cell differentiation during early human pancreas development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Glucolipotoxicity of the pancreatic beta-cell: myth or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

A pancreatic islet-specific microRNA regulates insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miR-375 maintains normal pancreatic alpha- and beta-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Homozygous mutations in NEUROD1 are responsible for a novel syndrome of permanent neonatal diabetes and neurological abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Sox9: a master regulator of the pancreatic program

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Rfx6 directs islet formation and insulin production in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Maternal microRNAs are essential for mouse zygotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Argonaute2 mediates compensatory expansion of the pancreatic β cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Dynamic expression of microRNAs during the differentiation of human embryonic stem cells into insulin-producing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Beta-cell adaptation and decompensation during the progression of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1miR-146.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA-19b downregulates insulin 1 through targeting transcription factor NeuroD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Circulating miR-375 as a biomarker of β-cell death and diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Effect of partial pancreatectomy on diabetic status in BALB/c mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

MicroRNA expression in alpha and beta cells of human pancreatic islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

Determination of 14 circulating microRNAs in Swedes and Iraqis with and without diabetes mellitus type 2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-0348-0955-9_10

10.1007/978-3-0348-0955-9_10

31 March 2020

Identifiers

DOI

1 reference

20 May 2018

1 reference

20 May 2018