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Akt and PTEN: beta-cell mass and pancreas plasticity.
scientific article published on 21 June 2009
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Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
review article
1 reference
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Europe PubMed Central
title
Akt and PTEN: beta-cell mass and pancreas plasticity
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
main subject
pancreas
0 references
author
Lynda Elghazi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
author name string
Ernesto Bernal-Mizrachi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
publication date
21 June 2009
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
published in
Trends in Endocrinology and Metabolism
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
volume
20
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
page(s)
243-251
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
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Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
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XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury
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Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
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Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dow
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion
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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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27 July 2018
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
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CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
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27 July 2018
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.
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27 July 2018
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity
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27 July 2018
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
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27 July 2018
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
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25 September 2018
Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination
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25 September 2018
PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
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25 September 2018
Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Wnt/beta-catenin signaling in development and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Stabilization of beta-catenin impacts pancreas growth.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Recent advances in the protein kinase B signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456182
retrieved
25 September 2018
Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19541499
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19541499
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19541499
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TEM.2009.03.002
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
PMC publication ID
4456182
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
PubMed publication ID
19541499
1 reference
stated in
Europe PubMed Central
PMC publication ID
4456182
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19541499%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
ResearchGate publication ID
26306275
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