(Q45098656)

9 December 2017

title

PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression (English)

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9 December 2017

Kyoko Nakamura

1

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9 December 2017

Hiroshi Sakaue

2

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9 December 2017

Akihiko Nishizawa

3

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9 December 2017

Yasushi Matsuki

4

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9 December 2017

Hideyuki Gomi

5

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9 December 2017

Eijiro Watanabe

6

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9 December 2017

Ryuji Hiramatsua

7

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9 December 2017

Mimi Tamamori-Adachi

8

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9 December 2017

Shigetaka Kitajima

9

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9 December 2017

Tetsuo Noda

10

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9 December 2017

Wataru Ogawa

11

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9 December 2017

Masato Kasuga

12

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9 December 2017

language of work or name

English

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publication date

22 April 2008

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Journal of Biological Chemistry

9 December 2017

published in

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9 December 2017

volume

283

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9 December 2017

issue

25

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9 December 2017

page(s)

17702-17711

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

9 December 2017

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21 January 2018

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21 January 2018

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Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

21 January 2018

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PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast

21 January 2018

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A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation

21 January 2018

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A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

21 January 2018

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PDK1 regulates growth through Akt and S6K in Drosophila

21 January 2018

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Essential role of PDK1 in regulating cell size and development in mice

21 January 2018

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The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

21 January 2018

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21 January 2018

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Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.

21 January 2018

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Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase

21 January 2018

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Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

21 January 2018

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

21 January 2018

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 January 2018

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The retinoblastoma protein and cell cycle control

21 January 2018

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The regulation of E2F by pRB-family proteins

21 January 2018

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Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein

21 January 2018

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21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

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Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin

21 January 2018

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

21 January 2018

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Regulation of cyclin-Cdk activity in mammalian cells

21 January 2018

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A model for restriction point control of the mammalian cell cycle.

21 January 2018

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G1 events and regulation of cell proliferation

21 January 2018

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G1 phase progression: cycling on cue

21 January 2018

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Cell cycle and death control: long live Forkheads

21 January 2018

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

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Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

21 January 2018

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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

21 January 2018

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

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A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

21 January 2018

1 reference

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802589200

21 January 2018

Identifiers

DOI

10.1074/JBC.M802589200

1 reference

9 December 2017

1 reference