(Q44839270)

6 December 2017

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development (English)

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6 December 2017

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6 December 2017

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6 December 2017

Heather J Hinton

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PubMed ID

15077109

6 December 2017

language of work or name

English

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publication date

11 April 2004

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6 December 2017

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6 December 2017

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6 December 2017

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6 December 2017

539-545

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https://scigraph.springernature.com/pub.10.1038/ni1062

6 December 2017

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cites work

On the brink of becoming a T cell.

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Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

21 January 2018

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Development of alphabeta T cells in the human thymus

21 January 2018

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Regulation and function of serine kinase networks in lymphocytes

21 January 2018

1 reference

T cell activation and the cytoskeleton

21 January 2018

1 reference

Transgenic analysis of thymocyte signal transduction

21 January 2018

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

1 reference

Regulation of hematopoietic cell development and activation by adapter proteins

21 January 2018

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Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

21 January 2018

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

21 January 2018

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Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

21 January 2018

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Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation

21 January 2018

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Immunodeficiency in protein kinase cbeta-deficient mice

21 January 2018

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Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Essential role of PDK1 in regulating cell size and development in mice

21 January 2018

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

21 January 2018

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Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene

21 January 2018

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Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

21 January 2018

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

21 January 2018

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Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

21 January 2018

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The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selection.

21 January 2018

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The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis

21 January 2018

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Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

21 January 2018

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

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Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

21 January 2018

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Phosphoinositide 3-kinases in T lymphocyte activation

21 January 2018

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PDK1 and PKB/Akt: ideal targets for development of new strategies to structure-based drug design

21 January 2018

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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Protein kinase Cδ controls self-antigen-induced B-cell tolerance

21 January 2018

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Intracellular Location and Cell Context-Dependent Function of Protein Kinase D

21 January 2018

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7 January 2021

PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

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7 January 2021

Pre-TCR signaling regulates IL-7 receptor α expression promoting thymocyte survival at the transition from the double-negative to double-positive stage

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7 January 2021

Different functions of the GTPase Rho in prothymocytes and late pre-T cells

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7 January 2021

The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1

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7 January 2021

The S6 kinase signaling pathway in the control of development and growth.

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7 January 2021

Identifiers

DOI

10.1038/NI1062

1 reference

PubMed ID

15077109

Dimensions Publication ID

6 December 2017

0 references

1 reference

PubMed ID

15077109