(Q54343211)

28 May 2018

title

The roles of intrinsic disorder in orchestrating the Wnt-pathway. (English)

1 reference

28 May 2018

author

Vladimir N. Uversky

3

0 references

author name string

Bin Xue

1

1 reference

28 May 2018

A Keith Dunker

2

1 reference

28 May 2018

Vladimir N Uversky

3

1 reference

28 May 2018

publication date

1 January 2012

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28 May 2018

Journal of Biomolecular Structure and Dynamics

published in

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28 May 2018

volume

29

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28 May 2018

issue

5

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28 May 2018

page(s)

843-861

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28 May 2018

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

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Role of backbone-solvent interactions in determining conformational equilibria of intrinsically disordered proteins

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21 January 2018

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Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome

21 January 2018

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21 January 2018

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Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

21 January 2018

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https://api.crossref.org/works/10.1080%2F073911012010525024

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

21 January 2018

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https://api.crossref.org/works/10.1080%2F073911012010525024

Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions

21 January 2018

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https://api.crossref.org/works/10.1080%2F073911012010525024

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

21 January 2018

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https://api.crossref.org/works/10.1080%2F073911012010525024

Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Disorder and sequence repeats in hub proteins and their implications for network evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Accessory proteins in signal transduction: scaffold proteins and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Functional classification of scaffold proteins and related molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Effect of the Wingless (wg1) mutation on wing and haltere development in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Alternative wnt signaling is initiated by distinct receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt signaling in disease and in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Mechanisms of Wnt signaling in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt pathway antagonists and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Association of the APC tumor suppressor protein with catenins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Association of the APC gene product with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt signaling controls the phosphorylation status of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The oncogenic activation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Identification of c-MYC as a target of the APC pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Pfam: a comprehensive database of protein domain families based on seed alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Sequence complexity of disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Length-dependent prediction of protein intrinsic disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Coupled folding and binding with alpha-helix-forming molecular recognition elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Wnt signaling: a common theme in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Functional domains of axin. Importance of the C terminus as an oligomerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Structural basis of the Axin-adenomatous polyposis coli interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Target site localization by site-specific, DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Obstacle bypass in protein motion along DNA by two-dimensional rather than one-dimensional sliding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystal Structure of a Full-Length β-Catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Three-dimensional structure of the armadillo repeat region of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Mechanistic insights from structural studies of beta-catenin and its binding partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The APC gene product in normal and tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

A repeating amino acid motif shared by proteins with diverse cellular roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Cell regulation by the Apc protein Apc as master regulator of epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Evolutionary rate heterogeneity in proteins with long disordered regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

21 January 2018

Evolution and disorder

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Conservation of intrinsic disorder in protein domains and families: I. A database of conserved predicted disordered regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Conservation of intrinsic disorder in protein domains and families: II. functions of conserved disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Close encounters of the third kind: disordered domains and the interactions of proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Analysis of molecular recognition features (MoRFs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin: a master scaffold for multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The links between axin and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

21 January 2018

Rethinking WNT signaling

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Predicting coiled coils from protein sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Predicting coiled coils by use of pairwise residue correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Retro-MoRFs: identifying protein binding sites by normal and reverse alignment and intrinsic disorder prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The importance of intrinsic disorder for protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Musite, a tool for global prediction of general and kinase-specific phosphorylation sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Identification, analysis, and prediction of protein ubiquitination sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Keepers at the final gates: regulatory complexes and gating of the proteasome channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Defining the geometry of the two-component proteasome degron

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

The type III secretion determinants of the flagellar anti-transcription factor, FlgM, extend from the amino-terminus into the anti-sigma28 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Preserving the membrane barrier for small molecules during bacterial protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F073911012010525024

10.1080/073911012010525024

21 January 2018

Identifiers

DOI

1 reference

28 May 2018

1 reference

28 May 2018