(Q54397189)

29 May 2018

title

Role of the unfolded protein response in organ physiology: lessons from mouse models. (English)

1 reference

29 May 2018

0 references

Víctor Hugo Cornejo

1

1 reference

29 May 2018

Philippe Pihán

series ordinal

2

1 reference

29 May 2018

René Luis Vidal

series ordinal

3

1 reference

29 May 2018

Claudio Hetz

series ordinal

4

1 reference

29 May 2018

publication date

13 November 2013

1 reference

29 May 2018

published in

IUBMB Life

1 reference

29 May 2018

volume

65

1 reference

29 May 2018

issue

12

1 reference

29 May 2018

page(s)

962-975

1 reference

29 May 2018

Signal integration in the endoplasmic reticulum unfolded protein response

cites work

1 reference

Targeting the unfolded protein response in disease.

21 January 2018

1 reference

The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

1 reference

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

1 reference

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

21 January 2018

1 reference

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

1 reference

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

21 January 2018

1 reference

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

21 January 2018

1 reference

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

21 January 2018

1 reference

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

1 reference

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

Activating transcription factor 4.

21 January 2018

1 reference

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

1 reference

ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo

21 January 2018

1 reference

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 January 2018

1 reference

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

21 January 2018

1 reference

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

21 January 2018

1 reference

IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level

21 January 2018

1 reference

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

21 January 2018

1 reference

The ER stress transducer IRE1β is required for airway epithelial mucin production

21 January 2018

1 reference

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

21 January 2018

1 reference

Negative feedback by IRE1β optimizes mucin production in goblet cells

21 January 2018

1 reference

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

21 January 2018

1 reference

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

21 January 2018

1 reference

Plasma cell differentiation requires the transcription factor XBP-1

21 January 2018

1 reference

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

21 January 2018

1 reference

X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function

21 January 2018

1 reference

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

21 January 2018

1 reference

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

21 January 2018

1 reference

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis

21 January 2018

1 reference

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

21 January 2018

1 reference

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

21 January 2018

1 reference

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

21 January 2018

1 reference

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

21 January 2018

1 reference

Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.

21 January 2018

1 reference

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

21 January 2018

1 reference

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

21 January 2018

1 reference

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

21 January 2018

1 reference

Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

21 January 2018

1 reference

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

21 January 2018

1 reference

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

21 January 2018

1 reference

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

21 January 2018

1 reference

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

21 January 2018

1 reference

Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.

21 January 2018

1 reference

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

1 reference

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

21 January 2018

1 reference

PERK in beta cell biology and insulin biogenesis

21 January 2018

1 reference

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

21 January 2018

1 reference

Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2

21 January 2018

1 reference

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

21 January 2018

1 reference

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

21 January 2018

1 reference

Gene-specific regulation by general translation factors

21 January 2018

1 reference

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

21 January 2018

1 reference

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

21 January 2018

1 reference

Atf4 regulates obesity, glucose homeostasis, and energy expenditure

21 January 2018

1 reference

ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.

21 January 2018

1 reference

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

21 January 2018

1 reference

Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

1 reference

The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice

21 January 2018

1 reference

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

21 January 2018

1 reference

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

21 January 2018

1 reference

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding

21 January 2018

1 reference

Chop-deficient mice showed increased adiposity but no glucose intolerance.

21 January 2018

1 reference

ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

21 January 2018

1 reference

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

21 January 2018

1 reference

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

1 reference

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

21 January 2018

1 reference

C/EBP homologous protein (CHOP) deficiency aggravates hippocampal cell apoptosis and impairs memory performance

21 January 2018

1 reference

Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury

21 January 2018

1 reference

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

21 January 2018

1 reference

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

21 January 2018

1 reference

Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors

21 January 2018

1 reference

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

21 January 2018

1 reference

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

21 January 2018

1 reference

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

21 January 2018

1 reference

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

21 January 2018

1 reference

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

21 January 2018

1 reference

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

21 January 2018

1 reference

XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells

21 January 2018

1 reference

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

21 January 2018

1 reference

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

21 January 2018

1 reference

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites

21 January 2018

1 reference

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

21 January 2018

1 reference

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation

21 January 2018

1 reference

XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum

21 January 2018

1 reference

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

21 January 2018

1 reference

Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1.

21 January 2018

1 reference

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

21 January 2018

1 reference

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

21 January 2018

1 reference

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease

21 January 2018

1 reference

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

21 January 2018

1 reference

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

21 January 2018

1 reference

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.

21 January 2018

1 reference

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

21 January 2018

1 reference

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

21 January 2018

1 reference

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

21 January 2018

1 reference

Regulation of basal cellular physiology by the homeostatic unfolded protein response

21 January 2018

1 reference

Cell-nonautonomous control of the UPR.

21 January 2018

1 reference

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IUB.1224

1 reference

29 May 2018

PubMed ID

24227223

1 reference

29 May 2018