(Q54635608)

1 June 2018

title

Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. (English)

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1 June 2018

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2

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Lucíola Silva Barcelos

3

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Andrea Doni

10

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Massimo Locati

13

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Remo Castro Russo

Remo C Russo

1

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Rodrigo Guabiraba

Rodrigo Guabiraba

5

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Milene A Rachid

Milene A Rachid

4

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Vanessa Pinho

Vanessa Pinho

12

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Mauro M Teixeira

14

Mauro M Teixeira

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1 June 2018

author name string

Ester Roffê

6

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1 June 2018

Adriano L S Souza

7

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Lirlândia P Sousa

8

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Massimiliano Mirolo

9

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Geovanni D Cassali

11

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publication date

2 November 2010

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Journal of Leukocyte Biology

published in

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volume

89

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issue

2

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1 June 2018

page(s)

269-282

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1 June 2018

The role of phosphoinositide 3-kinase lipid products in cell function

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Phosphatidylinositol-3-Kinase/Akt regulates bleomycin-induced fibroblast proliferation and collagen production

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Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

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The role of endothelial PI3Kgamma activity in neutrophil trafficking

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Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo

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Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease

21 January 2018

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Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury

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Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice.

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Biochemical and structural alterations of hamster lungs in response to intratracheal administration of bleomycin.

21 January 2018

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Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury

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Injury and repair in lung and airways

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Pulmonary fibrosis: pathogenesis, etiology and regulation

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The role of CXC chemokines in pulmonary fibrosis

21 January 2018

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Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis

21 January 2018

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PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

21 January 2018

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Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis

21 January 2018

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The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice

21 January 2018

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Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure

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Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.

21 January 2018

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The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality

21 January 2018

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Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.

21 January 2018

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Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases.

21 January 2018

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Pulmonary fibrosis correlates with duration of tissue neutrophil activation

21 January 2018

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Fine tuning the immune response with PI3K.

21 January 2018

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A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.

21 January 2018

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Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells

21 January 2018

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Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.

21 January 2018

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CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis

21 January 2018

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An essential role for fibronectin extra type III domain A in pulmonary fibrosis.

21 January 2018

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TGF-beta signaling and the fibrotic response

21 January 2018

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Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappaB.

21 January 2018

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PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner

21 January 2018

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Interleukin-10 and the interleukin-10 receptor

21 January 2018

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Leukocyte PI3K and PI3K have temporally distinct roles for leukocyte recruitment in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0610346

Phosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung

21 January 2018

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https://api.crossref.org/works/10.1189%2FJLB.0610346

Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury.

21 January 2018

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Inhibition of PI-3 kinase for treating respiratory disease: good idea or bad idea?

21 January 2018

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Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

21 January 2018

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The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8.

21 January 2018

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Angiogenesis and remodeling of airway vasculature in chronic inflammation

21 January 2018

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Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0610346

Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0610346

The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0610346

Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis

21 January 2018

1 reference

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Chemokine and chemokine receptor expression in keloid and normal fibroblasts

21 January 2018

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21 January 2018

Identifiers

DOI

10.1189/JLB.0610346

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1 June 2018

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1 June 2018