(Q55016820)

15 June 2018

title

Rescue of conformational dynamics in enzyme catalysis by directed evolution. (English)

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15 June 2018

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1

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15 June 2018

James S Fraser

8

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15 June 2018

author name string

Lin Liu

2

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15 June 2018

Lillian R Kenner

3

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15 June 2018

Michael W Clarkson

4

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15 June 2018

David Mavor

5

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15 June 2018

Dan S Tawfik

6

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15 June 2018

Dorothee Kern

7

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15 June 2018

language of work or name

English

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publication date

3 April 2018

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15 June 2018

published in

Nature Communications

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15 June 2018

volume

9

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15 June 2018

issue

1

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15 June 2018

page(s)

1314

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15 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

3 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-03562-9

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cites work

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Studying "invisible" excited protein states in slow exchange with a major state conformation

16 June 2018

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Towards automated crystallographic structure refinement with phenix.refine

16 June 2018

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16 June 2018

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16 June 2018

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At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

16 June 2018

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Role of prolyl cis/trans isomers in cyclophilin-assisted Pseudomonas syringae AvrRpt2 protease activation

16 June 2018

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Hidden alternative structures of proline isomerase essential for catalysis

16 June 2018

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Exploring protein fitness landscapes by directed evolution

16 June 2018

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A 21st century revisionist's view at a turning point in enzymology

16 June 2018

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16 June 2018

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Protein dynamism and evolvability.

16 June 2018

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16 June 2018

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16 June 2018

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An NMR perspective on enzyme dynamics

16 June 2018

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Intrinsic dynamics of an enzyme underlies catalysis

16 June 2018

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Enzyme dynamics during catalysis

16 June 2018

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Slow dynamics in folded and unfolded states of an SH3 domain

16 June 2018

1 reference

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Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization

16 June 2018

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16 June 2018

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Direct measurements of the dissociation-rate constant for inhibitor-enzyme complexes via the T1 rho and T2 (CPMG) methods.

16 June 2018

1 reference

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Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5883053

Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay

16 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5883053

16 June 2018

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Protein dynamics: Conformational footprints.

16 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5883053

Eukaryotic cyclophilin as a molecular switch for effector activation.

13 August 2018

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Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme

13 August 2018

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Measurement of slow (micros-ms) time scale dynamics in protein side chains by (15)N relaxation dispersion NMR spectroscopy: application to Asn and Gln residues in a cavity mutant of T4 lysozyme.

13 August 2018

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A method for determining B1 field inhomogeneity. Are the biases assumed in heteronuclear relaxation experiments usually underestimated?

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5883053

Kinetic Analysis of Cyclophilin-Catalyzed Prolyl Cis/Trans Isomerization by Dynamic NMR Spectroscopy

13 August 2018

1 reference

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Conformational Changes and Free Energies in a Proline Isomerase

13 August 2018

1 reference

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Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

30 November 2018

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https://api.crossref.org/works/10.1038%2FS41467-018-03562-9

7 January 2021

Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion

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7 January 2021

Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR

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7 January 2021

Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins

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7 January 2021

The Static Magnetic Field Dependence of Chemical Exchange Linebroadening Defines the NMR Chemical Shift Time Scale

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-03562-9

7 January 2021

10.1038/S41467-018-03562-9

Identifiers

DOI

1 reference

15 June 2018

Dimensions Publication ID

ADS bibcode

2018NatCo...9.1314O

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0 references

1 reference

15 June 2018

PubMed publication ID

29615624

1 reference

15 June 2018