(Q35763674)

10 August 2017

title

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways (English)

1 reference

10 August 2017

7

Lewis E Kay

1 reference

10 August 2017

Guillaume Bouvignies

5

0 references

author name string

Ashok Sekhar

1

1 reference

10 August 2017

Jessica A O Rumfeldt

2

1 reference

10 August 2017

Helen R Broom

3

1 reference

10 August 2017

Colleen M Doyle

4

1 reference

10 August 2017

Elizabeth M Meiering

6

1 reference

10 August 2017

language of work or name

English

0 references

publication date

23 June 2015

1 reference

10 August 2017

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10 August 2017

volume

4

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10 August 2017

page(s)

e07296

1 reference

Triple resonance-based ¹³C(α) and ¹³C(β) CEST experiments for studies of ms timescale dynamics in proteins

10 August 2017

cites work

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2 October 2017

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2 October 2017

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NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

2 October 2017

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Localized structural fluctuations promote amyloidogenic conformations in transthyretin

2 October 2017

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2 October 2017

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Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

2 October 2017

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Studying "invisible" excited protein states in slow exchange with a major state conformation

2 October 2017

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Structure of an intermediate state in protein folding and aggregation

2 October 2017

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2 October 2017

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Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease

2 October 2017

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2 October 2017

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Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS.

2 October 2017

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

2 October 2017

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On the measurement of ¹⁵N-{¹H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression

2 October 2017

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A transient and low-populated protein-folding intermediate at atomic resolution

2 October 2017

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

2 October 2017

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Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis

2 October 2017

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Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization

2 October 2017

1 reference

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Amyloid formation by globular proteins under native conditions

2 October 2017

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Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Consistent blind protein structure generation from NMR chemical shift data

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Measurement of bond vector orientations in invisible excited states of proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Protein structure determination from NMR chemical shifts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Mechanism of coupled folding and binding of an intrinsically disordered protein

2 October 2017

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Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

2 October 2017

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Identification of a collapsed intermediate with non-native long-range interactions on the folding pathway of a pair of Fyn SH3 domain mutants by NMR relaxation dispersion spectroscopy

2 October 2017

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Complementarity of ensemble and single-molecule measures of protein motion: a relaxation dispersion NMR study of an enzyme complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Detecting transient intermediates in macromolecular binding by paramagnetic NMR.

2 October 2017

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A simple method to predict protein flexibility using secondary chemical shifts

2 October 2017

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Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

2 October 2017

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Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers

2 October 2017

1 reference

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Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

2 October 2017

1 reference

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Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Structure and dynamics of copper-free SOD: The protein before binding copper

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

The solution structure of reduced dimeric copper zinc superoxide dismutase. The structural effects of dimerization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structure and function in an active enzyme

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

WHAT IF: a molecular modeling and drug design program

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Transient Hoogsteen base pairs in canonical duplex DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Contribution of conformational stability and reversibility of unfolding to the increased thermostability of human and bovine superoxide dismutase mutated at free cysteines.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Faster superoxide dismutase mutants designed by enhancing electrostatic guidance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Amyloid formation under physiological conditions proceeds via a native-like folding intermediate.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Measurement of slow (micros-ms) time scale dynamics in protein side chains by (15)N relaxation dispersion NMR spectroscopy: application to Asn and Gln residues in a cavity mutant of T4 lysozyme.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4475725

Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments

25 September 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Production and Incorporation of15N,13C,2H (1H-δ1 Methyl) Isoleucine into Proteins for Multidimensional NMR Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Sequence and structural determinants of Cu, Zn superoxide dismutase aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.07296

Sporadic amyotrophic lateral sclerosis with dementia and Cu/Zn superoxide dismutase-positive Lewy body-like inclusions

21 January 2018

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12 December 2020

13C NMR chemical shifts can predict disulfide bond formation

1 reference

12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

12 December 2020

Composition of soluble misfolded superoxide dismutase-1 in murine models of amyotrophic lateral sclerosis

1 reference

12 December 2020

A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity

1 reference

12 December 2020

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

1 reference

12 December 2020

The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy

1 reference

12 December 2020

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases

1 reference

12 December 2020

Amide proton temperature coefficients as hydrogen bond indicators in proteins

1 reference

12 December 2020

An NMR experiment for the accurate measurement of heteronuclear spin-lock relaxation rates

1 reference

12 December 2020

Probing slow chemical exchange at carbonyl sites in proteins by chemical exchange saturation transfer NMR spectroscopy

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.07296

1 reference

10 August 2017

1 reference

10 August 2017

1 reference