(Q55230708)

27 June 2018

title

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. (English)

1 reference

27 June 2018

1 reference

0 references

Stoyno Stoynov

20

0 references

Dragomir B Krastev

Dragomir B Krastev

2

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Sebastian Guettler

Sebastian Guettler

17

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Amanda Swain

Amanda Swain

16

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Christopher J Lord

Christopher J Lord

23

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Alan Ashworth

22

Alan Ashworth

1 reference

27 June 2018

10

James Campbell

1 reference

27 June 2018

Rachel Brough

9

Rachel Brough

1 reference

27 June 2018

Jessica R Frankum

11

Jessica Frankum

1 reference

27 June 2018

Rumana Rafiq

14

Rumana Rafiq

1 reference

27 June 2018

Kerry Fenwick

15

Kerry Fenwick

1 reference

27 June 2018

Stephen J Pettitt

1

Stephen J Pettitt

1 reference

27 June 2018

Feifei Song

5

Feifei Song

1 reference

27 June 2018

Inger Brandsma

3

Inger Brandsma

1 reference

27 June 2018

Amy Dréan

4

Amy Dréan

1 reference

27 June 2018

author name string

Radoslav Aleksandrov

6

1 reference

27 June 2018

Maria I Harrell

7

1 reference

27 June 2018

Malini Menon

8

1 reference

27 June 2018

Michael Ranes

12

1 reference

27 June 2018

Helen N Pemberton

13

1 reference

27 June 2018

Jung-Min Lee

18

1 reference

27 June 2018

Elizabeth M Swisher

19

1 reference

27 June 2018

Kosuke Yusa

21

1 reference

27 June 2018

language of work or name

English

0 references

publication date

10 May 2018

1 reference

27 June 2018

published in

Nature Communications

1 reference

27 June 2018

volume

9

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27 June 2018

issue

1

1 reference

27 June 2018

page(s)

1849

1 reference

27 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

10 May 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-03917-2

0 references

cites work

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

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Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-

30 June 2018

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Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

30 June 2018

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Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.

30 June 2018

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30 June 2018

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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

30 June 2018

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30 June 2018

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Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

30 June 2018

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30 June 2018

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The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

30 June 2018

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PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

30 June 2018

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TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

30 June 2018

1 reference

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Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

30 June 2018

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In vivo tumor growth of high-grade serous ovarian cancer cell lines

30 June 2018

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REV7 counteracts DNA double-strand break resection and affects PARP inhibition

30 June 2018

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Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

30 June 2018

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BRCA1 pathway function in basal-like breast cancer cells

30 June 2018

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Improved vectors and genome-wide libraries for CRISPR screening

30 June 2018

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CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

30 June 2018

1 reference

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Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

30 June 2018

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

30 June 2018

1 reference

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Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Genome-scale CRISPR-Cas9 knockout screening in human cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Comprehensive molecular portraits of human breast tumours

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

30 June 2018

1 reference

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High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Integrated genomic analyses of ovarian carcinoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

The enigmatic thymine DNA glycosylase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Role of poly(ADP-ribose) formation in DNA repair

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Detection of functional protein domains by unbiased genome-wide forward genetic screening.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Modeling Therapy Resistance in BRCA1/2-Mutant Cancers.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5945626

(ADP-ribose)n participates in DNA excision repair

30 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-018-03917-2

inferred from DOI database lookup

7 January 2021

based on heuristic

A shuttle mechanism for DNA-protein interactions. The regulation of poly(ADP-ribose) polymerase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29748565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Frequency of germline and somatic BRCA1 mutations in ovarian cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29748565

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/S41467-018-03917-2

1 reference

27 June 2018

Dimensions Publication ID

ADS bibcode

2018NatCo...9.1849P

0 references

0 references

1 reference

27 June 2018

PubMed publication ID

29748565

1 reference

27 June 2018