(Q55308550)

1 July 2018

title

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling. (English)

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1 July 2018

author name string

Sunyoung Ham

1

1 reference

1 July 2018

Luize G Lima

2

1 reference

1 July 2018

Edna Pei Zhi Chai

3

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1 July 2018

Alexandra Muller

4

1 reference

1 July 2018

Richard J Lobb

5

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1 July 2018

Sophie Krumeich

6

1 reference

1 July 2018

Shu Wen Wen

7

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1 July 2018

Adrian P Wiegmans

8

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1 July 2018

Andreas Möller

9

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1 July 2018

publication date

8 May 2018

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1 July 2018

published in

Frontiers in Immunology

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1 July 2018

volume

9

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1 July 2018

page(s)

871

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1 July 2018

Creative Commons Attribution 4.0 International

copyright license

start time

8 May 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer

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Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.

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3 July 2018

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Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes

3 July 2018

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3 July 2018

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Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype

3 July 2018

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Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells

3 July 2018

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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

3 July 2018

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Revisiting STAT3 signalling in cancer: new and unexpected biological functions

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Formation and role of exosomes in cancer

3 July 2018

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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

3 July 2018

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Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB.

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Functions and therapeutic roles of exosomes in cancer.

3 July 2018

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Microenvironmental regulation of tumor progression and metastasis

3 July 2018

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gp130: a promising drug target for cancer therapy

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Innate and adaptive immune cells in the tumor microenvironment

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo

3 July 2018

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The pre-metastatic niche: finding common ground

3 July 2018

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Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer

3 July 2018

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Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves

3 July 2018

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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

3 July 2018

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

STATs in cancer inflammation and immunity: a leading role for STAT3

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization

3 July 2018

1 reference

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3 July 2018

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Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

3 July 2018

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Inflammation and cancer: IL-6 and STAT3 complete the link.

3 July 2018

1 reference

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Inhibition of Siah ubiquitin ligase function.

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

3 July 2018

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Autocrine IL-6 signaling: a key event in tumorigenesis?

3 July 2018

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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

3 July 2018

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

3 July 2018

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Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy

3 July 2018

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Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5951966

Tumour-educated macrophages promote tumour progression and metastasis

3 July 2018

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

3 July 2018

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

3 July 2018

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Exosomes: composition, biogenesis and function

3 July 2018

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Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin.

3 July 2018

1 reference

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Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.

12 August 2018

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Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

12 August 2018

1 reference

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

12 August 2018

1 reference

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Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.

12 August 2018

1 reference

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Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases.

12 August 2018

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Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor

12 August 2018

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12 December 2020

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12 December 2020

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

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Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

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12 December 2020

The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes

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12 December 2020

Identifiers

DOI

10.3389/FIMMU.2018.00871

1 reference

1 July 2018

PMC publication ID

5951966

1 reference

1 July 2018

PubMed publication ID

29867925

1 reference

1 July 2018