(Q56449371)

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Therapies for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

ADAMs family members as amyloid precursor protein alpha-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Treatment of Alzheimer's disease: current status and new perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Emerging therapeutics for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

RIPped out by presenilin-dependent gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Gleevec inhibits β-amyloid production but not Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The nonfibrillar amyloid beta-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Alzhemed: a potential treatment for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Tau protein phosphorylation as a therapeutic target in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Prions: health scare and biological challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Mammalian prion biology: one century of evolving concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Selective expression of prion protein in peripheral tissues of the adult mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Developmental expression of the prion protein gene in glial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Distribution of cellular prion protein in normal human cerebral cortex--does it have relevance to Creutzfeldt-Jakob disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Cellular prion protein localization in rodent and primate brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Scrapie prion protein contains a phosphatidylinositol glycolipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The cellular prion protein binds copper in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Recombinant full-length murine prion protein, mPrP(23-231): purification and spectroscopic characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Insights into prion strains and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Patients with Alzheimer's disease and dementia with Lewy bodies mistaken for Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Prions prevent neuronal cell-line death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Effects of oxidative stress on prion protein expression in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Prion protein in Alzheimer’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Polymorphisms at codons 129 and 219 of the prion protein gene (PRNP) are not associated with sporadic Alzheimer's disease in the Korean population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Copper reduction by the octapeptide repeat region of prion protein: pH dependence and implications in cellular copper uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Dual mechanisms for shedding of the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Expression of cellular prion protein in the frontal and occipital lobe in Alzheimer's disease, diffuse Lewy body disease, and in normal brain: an immunohistochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Plasma membrane microdomains: organization, function and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The involvement of lipid rafts in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Alzheimer's disease: molecular concepts and therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Membrane topology influences N-glycosylation of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

Identification of the heparan sulfate binding sites in the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693

A systematic review of prion therapeutics in experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.6.693