(Q35166518)

6 August 2017

1 reference

title

RIPped out by presenilin-dependent gamma-secretase (English)

1 reference

6 August 2017

Miguel Medina

1

1 reference

6 August 2017

Carlos G Dotti

series ordinal

2

1 reference

6 August 2017

publication date

1 September 2003

1 reference

6 August 2017

number of pages

13

1 reference

inferred from page(s)

published in

Cellular Signalling

1 reference

6 August 2017

volume

15

1 reference

6 August 2017

issue

9

1 reference

6 August 2017

page(s)

829-841

1 reference

The presenilins and Alzheimer's disease

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Identification and characterization of presenilin I-467, I-463 and I-374.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Protein topology of presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Cell surface expression of the Alzheimer disease-related presenilin proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Characterization of Drosophila Presenilin and its colocalization with Notch during development

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Notch and presenilin: a proteolytic mechanism emerges

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Where Notch and Wnt signaling meet. The presenilin hub

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Erratum: Crystal structure of a bacterialsignal peptidase in complex with a β-lactam inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Untangling the ErbB signalling network

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

CD44 structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Signal transduction from the endoplasmic reticulum to the cell nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Cadherin cell adhesion molecules in differentiation and embryogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Cleavage and shedding of E-cadherin after induction of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Molecular architecture of adherens junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Nectin: an adhesion molecule involved in formation of synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Alzheimer's disease. A partner for presenilin.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900041-X

7 January 2021

10.1016/S0898-6568(03)00041-X

Identifiers

DOI

1 reference

6 August 2017

1 reference