(Q57419070)

5

object named as

J A Knight

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author name string

M D To

1

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N Gokgoz

2

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T G Doyle

3

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D B Donoviel

4

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P S Hyslop

6

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A Bernstein

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209397

7

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language of work or name

English

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publication date

13 February 2006

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published in

Oncogene

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volume

25

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page(s)

3557-3564

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issue

25

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exact match

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cites work

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Wide range in age of onset for chromosome 1--related familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Loss of heterozygosity on chromosome 1q in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

The presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Subcellular localization of presenilins during mouse preimplantation development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Notch signalling pathway and human diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Characteristics associated with participation at various stages at the Ontario site of the cooperative family registry for breast cancer studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

1 reference

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Assignment of Alzheimer's presenilin-2 (PS-2) gene to 1q42.1 by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209397

7 January 2021