(Q57658444)

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Ubiquinone-binding Site Mutations in theSaccharomyces cerevisiaeSuccinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate

scientific article published in Journal of Biological Chemistry

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2 January 2020

Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate (English)

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2 January 2020

Saccharomyces cerevisiae

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Stacey N Reinke

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2 January 2020

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Samuel S W Szeto

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2 January 2020

Brian D Sykes

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2 January 2020

Bernard D Lemire

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2 January 2020

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18 July 2007

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2 January 2020

Journal of Biological Chemistry

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2 January 2020

282

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2 January 2020

37

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2 January 2020

27518-27526

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2 January 2020

The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase

1 reference

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21 January 2018

The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase

1 reference

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21 January 2018

The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies

1 reference

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21 January 2018

Cytopathies involving mitochondrial complex II.

1 reference

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21 January 2018

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

1 reference

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21 January 2018

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

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21 January 2018

Inborn errors of complex II--unusual human mitochondrial diseases

1 reference

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21 January 2018

Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations

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21 January 2018

Mitochondrial tumour suppressors: a genetic and biochemical update

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The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction

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21 January 2018

Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant

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21 January 2018

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

1 reference

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21 January 2018

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability

1 reference

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21 January 2018

The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide

1 reference

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21 January 2018

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

1 reference

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21 January 2018

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

1 reference

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21 January 2018

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

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21 January 2018

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Novel mutations and the emergence of a common mutation in the SDHD gene causing familial paraganglioma

1 reference

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21 January 2018

The carboxyl terminus of the Saccharomyces cerevisiae succinate dehydrogenase membrane subunit, SDH4p, is necessary for ubiquinone reduction and enzyme stability.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

EPR studies on the respiratory chain of wild-type Saccharomyces cerevisiae and mutants with a deficiency in succinate dehydrogenase

1 reference

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21 January 2018

Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Architecture of succinate dehydrogenase and reactive oxygen species generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

The quinone-binding site in succinate-ubiquinone reductase from Escherichia coli. Quinone-binding domain and amino acid residues involved in quinone binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700601200

21 January 2018

Crystal structure of mitochondrial respiratory membrane protein complex II

1 reference

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21 January 2018

Identification of the heme axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase

1 reference

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21 January 2018

Flavinylation of succinate: ubiquinone oxidoreductase from Saccharomyces cerevisiae.

1 reference

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21 January 2018

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span

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21 January 2018

Animal models of Parkinson's disease.

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21 January 2018

Superoxide anion generation by the cytochrome bc1 complex

1 reference

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21 January 2018

The nuclear ABC1 gene is essential for the correct conformation and functioning of the cytochrome bc1 complex and the neighbouring complexes II and IV in the mitochondrial respiratory chain.

1 reference

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21 January 2018

Stoichiometry and compartmentation of NADH metabolism inSaccharomyces cerevisiae

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21 January 2018

The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II).

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21 January 2018

Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats

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Crystallization of mitochondrial respiratory complex II from chicken heart: a membrane-protein complex diffracting to 2.0 A

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21 January 2018

Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction

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21 January 2018

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

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The Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase. Identification of Sdh3p amino acid residues involved in ubiquinone binding

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The covalent attachment of FAD to the flavoprotein of Saccharomyces cerevisiae succinate dehydrogenase is not necessary for import and assembly into mitochondria

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One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556

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Assay of metabolic superoxide production in Escherichia coli.

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The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase

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1 reference

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1 reference

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10.1074/JBC.M700601200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17636259%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17636259%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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