(Q58173395)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24045153%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif (English)

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22 February 2020

1

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22 February 2020

Angus J.M. Cameron

7

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22 February 2020

Susanne Krüger Kjaer

10

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Peter Joseph Jacques Parker

22 February 2020

12

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22 February 2020

9

Andrew Purkiss

1 reference

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22 February 2020

8

Phillip Knowles

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22 February 2020

6

Carine Rosse

1 reference

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22 February 2020

5

Philippe Riou

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22 February 2020

3

Erika Soriano

1 reference

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22 February 2020

2

Marta Sanz-Garcia

1 reference

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22 February 2020

author name string

Yixiao Zhang

4

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22 February 2020

Neil Q McDonald

11

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22 February 2020

publication date

17 September 2013

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22 February 2020

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22 February 2020

volume

6

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22 February 2020

issue

293

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22 February 2020

page(s)

ra82

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

22 February 2020

cites work

1 reference

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The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

21 January 2018

1 reference

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aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

21 January 2018

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Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

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Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

21 January 2018

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Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma

21 January 2018

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Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis

21 January 2018

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High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence.

21 January 2018

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Involvement of PKC-iota in glioma proliferation

21 January 2018

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Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

21 January 2018

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Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study

21 January 2018

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SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

21 January 2018

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Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

21 January 2018

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Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

21 January 2018

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Aurothiomalate Inhibits Transformed Growth by Targeting the PB1 Domain of Protein Kinase Cι

21 January 2018

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Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota

21 January 2018

1 reference

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A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma

21 January 2018

1 reference

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An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCι in complex with a substrate peptide from Par-3

21 January 2018

1 reference

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A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

21 January 2018

1 reference

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Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

21 January 2018

1 reference

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

21 January 2018

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Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.

21 January 2018

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Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.

21 January 2018

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KIBRA is a novel substrate for protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis

21 January 2018

1 reference

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Coupling phosphoryl transfer and substrate interactions in protein kinases

21 January 2018

1 reference

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Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

21 January 2018

1 reference

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Molecular recognitions in the MAP kinase cascades

21 January 2018

1 reference

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Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

21 January 2018

1 reference

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Myristylation and palmitylation of Src family members: the fats of the matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity

21 January 2018

1 reference

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Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

21 January 2018

1 reference

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Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

21 January 2018

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Modelling glandular epithelial cancers in three-dimensional cultures

21 January 2018

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Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

21 January 2018

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Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

21 January 2018

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PATJ regulates tight junction formation and polarity in mammalian epithelial cells

21 January 2018

1 reference

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Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation

21 January 2018

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Myosin-X functions in polarized epithelial cells

21 January 2018

1 reference

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Myosin-X provides a motor-based link between integrins and the cytoskeleton.

21 January 2018

1 reference

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A microtubule-binding myosin required for nuclear anchoring and spindle assembly.

21 January 2018

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Cell signaling and function organized by PB1 domain interactions.

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

21 January 2018

1 reference

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The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

An unconventional myosin required for cell polarization and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Motor function and regulation of myosin X.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Myosin-X induces filopodia by multiple elongation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Myosin-10 and actin filaments are essential for mitotic spindle function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Mitotic spindle misorientation in cancer--out of alignment and into the fire

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004068

10.1126/SCISIGNAL.2004068

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24045153%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference