(Q59084697)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Martin A.M. Reijns

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Michael Aregger

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Jason Moffat

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Tatjana Stankovic

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Andrew Jackson

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

21

Johann de Bono

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

author name string

Michal Zimmermann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Angelo Agathanggelou

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Rachel Challis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Žygimantė Tarnauskaitė

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Morwenna Muir

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Adeline Fluteau

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Andrea McEwan

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Wei Yuan

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Matthew Clarke

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Maryou B Lambros

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Shankara Paneesha

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Paul Moss

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Megha Chandrashekhar

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Stephane Angers

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Valerie G Brunton

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Traver Hart

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Daniel Durocher

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

language of work or name

English

0 references

publication date

4 July 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

volume

559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

issue

7713

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

page(s)

285-289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

4 April 2020

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6071917/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6071917/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41586-018-0291-z

0 references

cites work

The long tail of oncogenic drivers in prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

PARP inhibitors: Synthetic lethality in the clinic

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Chronic lymphocytic leukaemia

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

The Balancing Act of Ribonucleotides in DNA

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

The Molecular Taxonomy of Primary Prostate Cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Integrative clinical genomics of advanced prostate cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Ligand-dependent enhancer activation regulated by topoisomerase-I activity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Easy quantitative assessment of genome editing by sequence trace decomposition

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Ribonuclease H2 in health and disease.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Improved vectors and genome-wide libraries for CRISPR screening

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Genome engineering using the CRISPR-Cas9 system

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

RNase H2 roles in genome integrity revealed by unlinking its activities

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6071917

10.1038/S41586-018-0291-Z

30 November 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29973717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

29973717

1 reference