(Q59292303)

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The eightfold path to non-enzymatic RNA replication

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title

The eightfold path to non-enzymatic RNA replication (English)

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1

Jack W Szostak

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publication date

2012

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published in

Journal of Systems Chemistry

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volume

3

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issue

1

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page(s)

2

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copyright license

Creative Commons Attribution 2.0 Generic

start time

3 February 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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stated in

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1759-2208-3-2

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cites work

Coupled Growth and Division of Model Protocell Membranes

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Real ribozymes suggest a relaxed error threshold

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Template-directed synthesis of a genetic polymer in a model protocell

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Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions

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Carbonyl sulfide-mediated prebiotic formation of peptides

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Prebiotic Chemistry and the Origin of the RNA World

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Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model

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A general two-metal-ion mechanism for catalytic RNA

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Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world

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Surprising fidelity of template-directed chemical ligation of oligonucleotides

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Adenosine residues in the template do not block spontaneous replication steps of RNA

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Catalysis of accurate poly(C)-directed synthesis of 3'-5'-linked oligoguanylates by Zn2+

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Thermostability of model protocell membranes

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Ribozyme-catalyzed transcription of an active ribozyme

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Asp537 and Asp812 in bacteriophage T7 RNA polymerase as metal ion-binding sites studied by EPR, flow-dialysis, and transcription

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Synthesis of long prebiotic oligomers on mineral surfaces.

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Derivatization of unprotected polynucleotides

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Interaction of metal ions with nucleic acids and related compounds. XVII. On the mechanism of degradation of polyribonucleotides and oligoribonucleotides by zinc(II) ions

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Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.

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Non-enzymatic transcription of an oligodeoxynucleotide 14 residues long

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Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity

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Extension of base mispairs by Taq DNA polymerase: implications for single nucleotide discrimination in PCR

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Chemoselective multicomponent one-pot assembly of purine precursors in water

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Molecular replication

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The case for an ancestral genetic system involving simple analogues of the nucleotides

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Prebiotic chemistry: a new modus operandi

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Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding

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In silico simulations reveal that replicators with limited dispersal evolve towards higher efficiency and fidelity

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Selection of an improved RNA polymerase ribozyme with superior extension and fidelity

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Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication

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Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA.

1 reference

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Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution

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Identifiers

DOI

10.1186/1759-2208-3-2

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Dimensions Publication ID

1023909574

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(Q59292303)

The eightfold path to non-enzymatic RNA replication

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