(Q60325954)

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A Specific Picomolar Hybridization-Based ELISA Assay for the Determination of Phosphorothioate Oligonucleotides in Plasma and Cellular Matrices

scientific article published on 25 May 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

3

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Guido Marcucci

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Xiaohui Wei

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Guowei Dai

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Zhongfa Liu

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Dale Hoyt

5

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Europe PubMed Central

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28 January 2020

William Blum

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Guido Marcucci

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Kenneth K Chan

7

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Europe PubMed Central

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28 January 2020

publication date

25 May 2006

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Pharmaceutical Research

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

23

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28 January 2020

6

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1251-1264

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0082-3

21 January 2018

A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects*

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of capillary electrophoresis methods to characterize the pharmacokinetics of antisense drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense therapy for cancer--the time of truth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of phosphorothioate oligonucleotides in biological fluids using fast anion-exchange chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of Oligodeoxynucleotides in Human Plasma with a Novel Hybridization Assay Offers Greatly Enhanced Sensitivity over Capillary Gel Electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense oligonucleotides: basic concepts and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and validation of a sensitive, specific, and rapid hybridization-ELISA assay for determination of concentrations of a ribozyme in biological matrices

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense oligonucleotide-based therapeutics for cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of novel quantitative bioanalytical methods for pharmacokinetic and pharmacokinetic/pharmacodynamic assessments of antisense oligonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GTI-2040, an antisense agent targeting the small subunit component (R2) of human ribonucleotide reductase, shows potent antitumor activity against a variety of tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense therapy in oncology: new hope for an old idea?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16718617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-006-0082-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16718617%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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