(Q60595374)

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TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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Europe PubMed Central

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4 January 2020

4

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Europe PubMed Central

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4 January 2020

author name string

Kyung-Hyun Park-Min

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Taras Antoniv

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Lionel B Ivashkiv

5

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Europe PubMed Central

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4 January 2020

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16 March 2008

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Europe PubMed Central

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4 January 2020

Nature Immunology

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18345002%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

4

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Europe PubMed Central

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4 January 2020

378-387

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Europe PubMed Central

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4 January 2020

https://scigraph.springernature.com/pub.10.1038/ni1576

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Toll-like receptor signalling

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IRF3 mediates a TLR3/TLR4-specific antiviral gene program

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock

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Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

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Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

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Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

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Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-β production in myeloid dendritic cells

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7 January 2021

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

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7 January 2021

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IRF family of transcription factors as regulators of host defense

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Roles of interferon-regulatory factors in T-helper-cell differentiation

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Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein

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Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1.

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Alternative activation of macrophages

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Achieving stability of lipopolysaccharide-induced NF-kappaB activation

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Stimulus specificity of gene expression programs determined by temporal control of IKK activity

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Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

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Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors

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Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.

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IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes.

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Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

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Identification of a novel cytokine response element in the human IFN regulatory factor-1 gene promoter

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Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors

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