(Q60950025)

English

Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches

scientific article published on 18 December 2018

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

gastroenterology

0 references

1 reference

based on heuristic

inferred from title

invasive ductal carcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal carcinoma

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

Pietro Parcesepe

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

Massimo Pancione

6

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Europe PubMed Central

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19 April 2020

8

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Europe PubMed Central

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19 April 2020

10

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Europe PubMed Central

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19 April 2020

author name string

Claudia Covelli

3

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19 April 2020

Nunzio Olivieri

4

1 reference

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19 April 2020

Andrea Remo

5

1 reference

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19 April 2020

Tiziana Pia Latiano

7

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Europe PubMed Central

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19 April 2020

Evaristo Maiello

9

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Europe PubMed Central

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19 April 2020

language of work or name

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publication date

18 December 2018

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Europe PubMed Central

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19 April 2020

Gastroenterology research and practice

1 reference

Europe PubMed Central

PMC publication ID

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19 April 2020

2018

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

7530619

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

copyright license

Creative Commons Attribution 4.0 International

18 December 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

0 references

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblasts in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic stellate cells: partners in crime with pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of TGF-beta in the tumor stroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-derived suppressor cells as regulators of the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of M2-polarized tumor-associated macrophage in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of fibroblasts in cancer stroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-infiltrating neutrophils in pancreatic neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived proangiogenic cells in pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rationale for targeting the LOX family in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pancreas cancer microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor microenvironment at a glance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of bone marrow derived cells to the pancreatic tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mucins in pancreatic cancer and its microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target therapies in pancreatic carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic tumor cell metabolism: focus on glycolysis and its connected metabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-associated macrophages: from mechanisms to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1α expression and its clinical significance in pancreatic cancer: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microenvironmental regulation of therapeutic response in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic factors of survival in a randomized phase III trial (MPACT) of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole genomes redefine the mutational landscape of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer: The microenvironment needs attention too!

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stromal biology and therapy in pancreatic cancer: a changing paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological hallmarks of stromal cells in the tumour microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hypoxia in pancreatic cancer: a potential therapeutic target?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages and pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor angiogenesis--characteristics of tumor endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic analyses identify molecular subtypes of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More deaths from pancreatic cancer than breast cancer in the EU by 2017.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of PDL1 expression in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pericyte-fibroblast transition promotes tumor growth and metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of immune cells in pancreatic cancer from bench to clinical application: An updated review

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between stromal cells and cancer cells in pancreatic cancer: New insights into stromal biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic stellate cell: Pandora's box for pancreatic disease biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pancreatic cancer microenvironment: A true double agent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Roles of Matrix Metalloproteinases in Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1/PD-L1 and immunotherapy for pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer associated fibroblasts: An essential role in the tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy in pancreatic ductal adenocarcinoma: an emerging entity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microenvironmental periostin in pancreatic cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The predictive value and role of stromal tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma (PDAC).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer statistics, 2018.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A meta-analysis of the utility of the neutrophil-to-lymphocyte ratio in predicting survival after pancreatic cancer resection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial-Mesenchymal Transition in Pancreatic Cancer: A Review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy and radiotherapy for advanced pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30662458

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2018/7530619

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30662458%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

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