(Q63437314)

2

0 references

Gang Yang

3

0 references

Huanyu Wang

4

0 references

Mengyu Feng

5

0 references

Lei You

6

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Yupei Zhao

Creative Commons Attribution 4.0 International

7

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language of work or name

English

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publication date

30 July 2018

3 references

19 June 2019

7 August 2019

8 September 2020

3 references

19 June 2019

7 August 2019

8 September 2020

17

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issue

1

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page(s)

108

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copyright license

3 references

Europe PubMed Central

19 June 2019

Europe PubMed Central

7 August 2019

Europe PubMed Central

on focus list of Wikimedia project

8 September 2020

ScienceSource

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exact match

https://scigraph.springernature.com/pub.10.1186/s12943-018-0858-1

0 references

cites work

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

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12 December 2020

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses

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12 December 2020

Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand

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12 December 2020

Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer

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12 December 2020

Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients

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12 December 2020

Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells

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12 December 2020

Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas

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12 December 2020

Generation of multiple angiogenesis inhibitors by human pancreatic cancer

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12 December 2020

Tumor-associated macrophages: a molecular perspective

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12 December 2020

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

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12 December 2020

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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12 December 2020

Modulation of tryptophan catabolism by regulatory T cells.

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12 December 2020

Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer

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12 December 2020

CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma

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12 December 2020

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

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12 December 2020

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

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12 December 2020

Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses

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12 December 2020

The chemokine system in diverse forms of macrophage activation and polarization

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12 December 2020

Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis

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12 December 2020

Macrophage inflammatory protein-3alpha promotes pancreatic cancer cell invasion.

1 reference

12 December 2020

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

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12 December 2020

Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion.

1 reference

12 December 2020

Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma

1 reference

12 December 2020

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

1 reference

12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

12 December 2020

Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

1 reference

12 December 2020

The tumor-draining lymph node as an immune-privileged site

1 reference

12 December 2020

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

1 reference

12 December 2020

The pancreatic stellate cell: a star on the rise in pancreatic diseases

1 reference

12 December 2020

Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity

1 reference

12 December 2020

A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment

1 reference

12 December 2020

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells

1 reference

12 December 2020

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

1 reference

12 December 2020

MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells

1 reference

12 December 2020

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 reference

12 December 2020

The pathology and genetics of metastatic pancreatic cancer

1 reference

12 December 2020

Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer

1 reference

12 December 2020

Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells.

1 reference

12 December 2020

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism

1 reference

12 December 2020

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

1 reference

12 December 2020

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

1 reference

12 December 2020

Significance of M2-polarized tumor-associated macrophage in pancreatic cancer

1 reference

12 December 2020

CD44v6 dependence of premetastatic niche preparation by exosomes

1 reference

12 December 2020

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

1 reference

12 December 2020

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.

1 reference

12 December 2020

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

1 reference

12 December 2020

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

1 reference

12 December 2020

miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.

1 reference

12 December 2020

CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer

1 reference

12 December 2020

Significance of lymphangiogenesis in primary tumor and draining lymph nodes during lymphatic metastasis of pancreatic head cancer

1 reference

12 December 2020

Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer

1 reference

12 December 2020

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer

1 reference

12 December 2020

Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1α in cancer cells

1 reference

12 December 2020

High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer

1 reference

12 December 2020

Nuclear factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions

1 reference

12 December 2020

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

1 reference

12 December 2020

Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer

1 reference

12 December 2020

The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer

1 reference

12 December 2020

Blocking IDO activity to enhance anti-tumor immunity.

1 reference

12 December 2020

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.

1 reference

12 December 2020

Lymphangiogenesis and biological behavior in pancreatic carcinoma and other pancreatic tumors

1 reference

12 December 2020

EMT and dissemination precede pancreatic tumor formation

1 reference

12 December 2020

Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells

1 reference

12 December 2020

Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

1 reference

12 December 2020

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Pancreatic cancer stem cells: emerging target for designing novel therapy

1 reference

12 December 2020

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

1 reference

12 December 2020

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

1 reference

12 December 2020

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

1 reference

12 December 2020

M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer

1 reference

12 December 2020

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

1 reference

12 December 2020

Macrophages in tumor microenvironments and the progression of tumors

1 reference

12 December 2020

Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene

1 reference

12 December 2020

MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors

1 reference

12 December 2020

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

1 reference

12 December 2020

Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells

1 reference

12 December 2020

VEGF-C ShRNA inhibits pancreatic cancer growth and lymphangiogenesis in an orthotopic fluorescent nude mouse model.

1 reference

12 December 2020

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

1 reference

12 December 2020

Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner

1 reference

12 December 2020

Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.

1 reference

12 December 2020

Biology and clinical applications of pancreatic cancer stem cells

1 reference

12 December 2020

Understanding and targeting cancer stem cells: therapeutic implications and challenges

1 reference

12 December 2020

M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway

1 reference

12 December 2020

Canonical wnt signaling is required for pancreatic carcinogenesis

1 reference

12 December 2020

Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma

1 reference

12 December 2020

HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression

1 reference

12 December 2020

Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer

1 reference

12 December 2020

Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway

1 reference

12 December 2020

Alterations in macrophages and monocytes from tumor-bearing mice: evidence of local and systemic immune impairment.

1 reference

12 December 2020

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.

1 reference

12 December 2020

Expression and prognostic value of c-Myc and Fas (CD95/APO1) in patients with pancreatic cancer

1 reference

12 December 2020

Notch pathway activation is associated with pancreatic cancer treatment failure.

1 reference

12 December 2020

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.

1 reference

12 December 2020

Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer

1 reference

12 December 2020

An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma

1 reference

12 December 2020

The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer

1 reference

12 December 2020

Tumour-educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion

1 reference

12 December 2020

The M1 and M2 paradigm of macrophage activation: time for reassessment

1 reference

12 December 2020

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

1 reference

12 December 2020

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

1 reference

12 December 2020

Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy.

1 reference

12 December 2020

Cancer immunology. Identifying the infiltrators

1 reference

12 December 2020

Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer.

1 reference

12 December 2020

Complex role for the immune system in initiation and progression of pancreatic cancer.

1 reference

12 December 2020

FOXP3+ lymphocyte density in pancreatic cancer correlates with lymph node metastasis

1 reference

12 December 2020

Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas

1 reference

12 December 2020

Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

1 reference

12 December 2020

Overexpression of membrane-type 2 matrix metalloproteinase induced by hypoxia-inducible factor-1α in pancreatic cancer: Implications for tumor progression and prognosis

1 reference

12 December 2020

Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease

1 reference

12 December 2020

Macrophage heterogeneity in tissues: phenotypic diversity and functions

1 reference

12 December 2020

Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions

1 reference

12 December 2020

ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells

1 reference

12 December 2020

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival.

1 reference

12 December 2020

Immune cell promotion of metastasis

1 reference

12 December 2020

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

1 reference

12 December 2020

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

1 reference

12 December 2020

Macrophages and cancer: from mechanisms to therapeutic implications

1 reference

12 December 2020

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

1 reference

12 December 2020

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

1 reference

12 December 2020

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

1 reference

12 December 2020

Stromal biology and therapy in pancreatic cancer: a changing paradigm

1 reference

12 December 2020

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

1 reference

12 December 2020

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

1 reference

12 December 2020

Changes of Th17/Treg cell and related cytokines in pancreatic cancer patients

1 reference

12 December 2020

Combination cancer immunotherapy and new immunomodulatory targets

1 reference

12 December 2020

TRAIL Promotes Tumor Growth in a Syngeneic Murine Orthotopic Pancreatic Cancer Model and Affects the Host Immune Response

1 reference

12 December 2020

IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

1 reference

12 December 2020

Tumour exosome integrins determine organotropic metastasis.

1 reference

12 December 2020

The role of hypoxia in pancreatic cancer: a potential therapeutic target?

1 reference

12 December 2020

Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

1 reference

12 December 2020

Targeting the indoleamine 2,3-dioxygenase pathway in cancer

1 reference

12 December 2020

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

1 reference

12 December 2020

The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer

1 reference

12 December 2020

Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer

1 reference

12 December 2020

TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

1 reference

12 December 2020

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

1 reference

12 December 2020

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

1 reference

12 December 2020

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

1 reference

12 December 2020

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

1 reference

12 December 2020

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

1 reference

12 December 2020

Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma

1 reference

12 December 2020

Pancreatic cancer biology and genetics from an evolutionary perspective

1 reference

12 December 2020

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver

1 reference

12 December 2020

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

1 reference

12 December 2020

Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer.

1 reference

12 December 2020

Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma

1 reference

12 December 2020

Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells.

1 reference

12 December 2020

Characteristics and Significance of the Pre-metastatic Niche

1 reference

12 December 2020

Myeloid-derived suppressor cells and their role in pancreatic cancer

1 reference

12 December 2020

Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Crosstalk between stromal cells and cancer cells in pancreatic cancer: New insights into stromal biology

1 reference

12 December 2020

Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway

1 reference

12 December 2020

Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis.

1 reference

12 December 2020

Biology of pancreatic stellate cells-more than just pancreatic cancer

1 reference

12 December 2020

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

1 reference

12 December 2020

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

1 reference

12 December 2020

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

1 reference

12 December 2020

Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor /c-Met/survivin regulated by P53/P21.

1 reference

12 December 2020

PD-1/PD-L1 and immunotherapy for pancreatic cancer

1 reference

12 December 2020

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms

1 reference

12 December 2020

Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice

1 reference

12 December 2020

Xanthohumol inhibits angiogenesis by suppressing nuclear factor-κB activation in pancreatic cancer.

1 reference

12 December 2020

PSC-derived Galectin-1 inducing epithelial-mesenchymal transition of pancreatic ductal adenocarcinoma cells by activating the NF-κB pathway

1 reference

12 December 2020

Role of microenvironmental periostin in pancreatic cancer progression

1 reference

12 December 2020

Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma

1 reference

12 December 2020

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

1 reference

12 December 2020

Cancer statistics, 2018.

1 reference

12 December 2020

The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.

1 reference

12 December 2020