(Q64055907)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30845728%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

title

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment (English)

1 reference

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27 April 2020

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2

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27 April 2020

Lijiao Zhao

4

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27 April 2020

author name string

Tengjiao Fan

1

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27 April 2020

Xiaodong Sun

3

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27 April 2020

Rugang Zhong

5

1 reference

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27 April 2020

Yongzhen Peng

6

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27 April 2020

language of work or name

English

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publication date

6 March 2019

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27 April 2020

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27 April 2020

volume

11

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27 April 2020

issue

3

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Creative Commons Attribution 4.0 International

27 April 2020

page(s)

317

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copyright license

start time

6 March 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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12 December 2020

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12 December 2020

Bromopyruvate inactivation of glutamate apodecarboxylase. Kinetics and specificity

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12 December 2020

Alkylation of isocitrate lyase from Escherichia coli by 3-bromopyruvate.

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12 December 2020

Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus

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12 December 2020

Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC

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12 December 2020

Affinity labels for the anion-binding site in ovotransferrin

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12 December 2020

Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line

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12 December 2020

Effects of bromopyruvate on the control and catalytic properties of glutamate dehydrogenase

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12 December 2020

The inactivation of succinate dehydrogenase by bromopyruvate

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12 December 2020

Bromopyruvate as an active-site-directed inhibitor of the pyruvate dehydrogenase multienzyme complex from Escherichia coli

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12 December 2020

Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding

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12 December 2020

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

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12 December 2020

How do mutated oncogenes and tumor suppressor genes cause cancer?

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12 December 2020

Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

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12 December 2020

Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis

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12 December 2020

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

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12 December 2020

Modification of human erythrocyte pyruvate kinase by an active site-directed reagent: bromopyruvate

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12 December 2020

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

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12 December 2020

Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase.

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12 December 2020

Laboratory markers of melanoma progression

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12 December 2020

SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

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12 December 2020

On the Origin of Cancer Cells

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12 December 2020

Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma

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12 December 2020

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

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12 December 2020

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

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12 December 2020

Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.

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12 December 2020

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

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12 December 2020

GAPDH as a sensor of NO stress

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12 December 2020

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

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12 December 2020

Inactivation of H+-vacuolar ATPase by the energy blocker 3-bromopyruvate, a new antitumour agent

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12 December 2020

Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model.

1 reference

12 December 2020

Intraarterial Therapy with a New Potent Inhibitor of Tumor Metabolism (3-bromopyruvate): Identification of Therapeutic Dose and Method of Injection in an Animal Model of Liver Cancer

1 reference

12 December 2020

Energy metabolism in tumor cells

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12 December 2020

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.

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12 December 2020

Pyruvate kinase M2 is a phosphotyrosine-binding protein

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12 December 2020

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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12 December 2020

Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor

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12 December 2020

Sodium-coupled monocarboxylate transporters in normal tissues and in cancer

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12 December 2020

Glycolytic enzyme inhibitors in cancer treatment

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12 December 2020

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate

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12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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12 December 2020

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

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12 December 2020

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

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12 December 2020

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

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12 December 2020

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

1 reference

12 December 2020

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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12 December 2020

Targets of 3-bromopyruvate, a new, energy depleting, anticancer agent.

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12 December 2020

Silencing hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.

1 reference

12 December 2020

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

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12 December 2020

Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

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12 December 2020

THE METABOLISM OF TUMORS IN THE BODY

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12 December 2020

Identification of small molecule inhibitors of pyruvate kinase M2

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12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death

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12 December 2020

ABC transporters in cancer: more than just drug efflux pumps.

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12 December 2020

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines

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12 December 2020

The diverse functions of GAPDH: views from different subcellular compartments

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12 December 2020

Human pyruvate kinase M2: a multifunctional protein

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12 December 2020

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma

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12 December 2020

Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

Targeting cancer metabolism: a therapeutic window opens

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12 December 2020

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells

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12 December 2020

Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

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12 December 2020

The monocarboxylate transporter family--role and regulation

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12 December 2020

3-Bromopyruvate: targets and outcomes

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12 December 2020

Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies

1 reference

12 December 2020

A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

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12 December 2020

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

1 reference

12 December 2020

Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester

1 reference

12 December 2020

Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists

1 reference

12 December 2020

Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity

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12 December 2020

Novel insight into the role of GAPDH playing in tumor

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12 December 2020

Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells

1 reference

12 December 2020

Advances in mycobacterial isocitrate lyase targeting and inhibitors.

1 reference

12 December 2020

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

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12 December 2020

Antiglycolytic therapy combined with an image-guided minimally invasive delivery strategy for the treatment of breast cancer

1 reference

12 December 2020

3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans

1 reference

12 December 2020

The expression of glyceraldehyde-3-phosphate dehydrogenase associated cell cycle (GACC) genes correlates with cancer stage and poor survival in patients with solid tumors

1 reference

12 December 2020

Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model

1 reference

12 December 2020

Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation

1 reference

12 December 2020

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

1 reference

12 December 2020

Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma

1 reference

12 December 2020

Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionizatio

1 reference

12 December 2020

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

1 reference

12 December 2020

The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions

1 reference

12 December 2020

3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes.

1 reference

12 December 2020

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

1 reference

12 December 2020

The reversal effects of 3-bromopyruvate on multidrug resistance in vitro and in vivo derived from human breast MCF-7/ADR cells

1 reference

12 December 2020

Deregulation of glyceraldehyde-3-phosphate dehydrogenase expression during tumor progression of human cutaneous melanoma

1 reference

12 December 2020

The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH.

1 reference

12 December 2020

Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.

1 reference

12 December 2020

Effect of 3-bromopyruvate and atovaquone on infection during in vitro interaction of Toxoplasma gondii and LLC-MK2 cells.

1 reference

12 December 2020

Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis.

1 reference

12 December 2020

The Induction and Repair of DNA Interstrand Crosslinks and Implications in Cancer Chemotherapy

1 reference

12 December 2020

Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines

1 reference

12 December 2020

3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system.

1 reference

12 December 2020

3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells

1 reference

12 December 2020

Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells.

1 reference

12 December 2020

The Warburg Effect: How Does it Benefit Cancer Cells?

1 reference

12 December 2020

Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione.

1 reference

12 December 2020

3-Bromopyruvic Acid Inhibits Tricarboxylic Acid Cycle and Glutaminolysis in HepG2 Cells

1 reference

12 December 2020

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside.

1 reference

12 December 2020

ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid.

1 reference

12 December 2020

Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

1 reference

12 December 2020

3-Bromopyruvate treatment induces alterations of metabolic and stress-related pathways in glioblastoma cells

1 reference

12 December 2020

The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

1 reference

12 December 2020

The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view.

1 reference

12 December 2020

The potential of combi-molecules with DNA-damaging function as anticancer agents

1 reference

12 December 2020

3-bromopyruvate and buthionine sulfoximine effectively kill anoikis-resistant hepatocellular carcinoma cells

1 reference

12 December 2020

Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism

1 reference

12 December 2020

A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells.

1 reference

12 December 2020

Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis

1 reference

12 December 2020

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

1 reference

12 December 2020

Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death.

1 reference

12 December 2020

Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis

1 reference

12 December 2020

Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells.

1 reference

12 December 2020

Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: Implication of niche dependent differential roles of macrophages.

1 reference

12 December 2020

3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis.

1 reference

12 December 2020

The specific role of O-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy

1 reference

12 December 2020

3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

1 reference

12 December 2020

Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity

1 reference

12 December 2020

Enhancing anticancer effects, decreasing risks and solving practical problems facing 3-bromopyruvate in clinical oncology: 10 years of research experience

1 reference

12 December 2020

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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12 December 2020

Positron emission tomography/computed tomography in the diagnosis, staging, and prognostic evaluation of natural killer/T-cell lymphoma

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12 December 2020

18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS11030317

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30845728%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30845728%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference