(Q64071499)

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MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF amplification whereas KRAS amplification promotes EMT-chemoresistance

scientific article published on 02 May 2019

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24 April 2020

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance (English)

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24 April 2020

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24 April 2020

Julio Saez-Rodriguez

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24 April 2020

author name string

Matthew J Sale

1

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24 April 2020

Kathryn Balmanno

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24 April 2020

Jayeta Saxena

3

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24 April 2020

Katarzyna Wojdyla

5

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24 April 2020

Rebecca E McIntyre

6

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24 April 2020

Rebecca Gilley

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24 April 2020

Anna Woroniuk

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24 April 2020

Karen D Howarth

9

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24 April 2020

Gareth Hughes

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24 April 2020

Jonathan R Dry

11

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24 April 2020

Pilar Caro

13

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24 April 2020

David Oxley

14

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24 April 2020

Susan Ashton

15

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24 April 2020

David J Adams

16

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24 April 2020

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2 May 2019

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24 April 2020

Nature Communications

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24 April 2020

10

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24 April 2020

1

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24 April 2020

2030

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24 April 2020

copyright license

Creative Commons Attribution 4.0 International

2 May 2019

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April 2022 Public Data File from Crossref

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6497655/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

1 reference

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/6497655

based on heuristic

inferred from PubMed Central ID database lookup

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved survival with MEK inhibition in BRAF-mutated melanoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of acquired resistance to ERK1/2 pathway inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

MEK1 mutations confer resistance to MEK and B-RAF inhibition

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

ERK inhibition overcomes acquired resistance to MEK inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

BRAFE600-associated senescence-like cell cycle arrest of human naevi

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Wildtype Kras2 can inhibit lung carcinogenesis in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p57(KIP2) during muscle differentiation: role of Egr1, Sp1 and DNA hypomethylation

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

p57KIP2: "Kip"ing the cell under control.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Exploiting drug addiction mechanisms to select against MAPKi-resistant melanoma.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse models of colorectal cancer as preclinical models

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

Real-time quantitative RT-PCR: design, calculations, and statistics.

1 reference

https://api.crossref.org/works/10.1038%2FS41467-019-09438-W

7 January 2021

based on heuristic

inferred from DOI database lookup

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/31048689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/S41467-019-09438-W

1 reference

Europe PubMed Central

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24 April 2020

2019NatCo..10.2030S

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1 reference

Europe PubMed Central

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24 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31048689%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

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