(Q64272038)

12 December 2020

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

12 December 2020

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

12 December 2020

Sir2 links chromatin silencing, metabolism, and aging

1 reference

12 December 2020

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

1 reference

12 December 2020

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

12 December 2020

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

12 December 2020

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

12 December 2020

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

1 reference

12 December 2020

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination

1 reference

12 December 2020

Cancer and aging: a model for the cancer promoting effects of the aging stroma

1 reference

12 December 2020

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.

1 reference

12 December 2020

A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span

1 reference

12 December 2020

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

1 reference

12 December 2020

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.

1 reference

12 December 2020

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

1 reference

12 December 2020

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

1 reference

12 December 2020

Calorie restriction extends yeast life span by lowering the level of NADH.

1 reference

12 December 2020

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

12 December 2020

Sirtuins: Sir2-related NAD-dependent protein deacetylases

1 reference

12 December 2020

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

12 December 2020

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

1 reference

12 December 2020

The interaction between FOXO and SIRT1: tipping the balance towards survival

1 reference

12 December 2020

Sir2-independent life span extension by calorie restriction in yeast

1 reference

12 December 2020

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

1 reference

12 December 2020

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

1 reference

12 December 2020

Replicative senescence: a critical review.

1 reference

12 December 2020

Substrate-specific activation of sirtuins by resveratrol

1 reference

12 December 2020

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition

1 reference

12 December 2020

Mechanism of human SIRT1 activation by resveratrol

1 reference

12 December 2020

Toward a unified theory of caloric restriction and longevity regulation

1 reference

12 December 2020

Calorie restriction and SIR2 genes--towards a mechanism

1 reference

12 December 2020

HST2 mediates SIR2-independent life-span extension by calorie restriction

1 reference

12 December 2020

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

1 reference

12 December 2020

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

1 reference

12 December 2020

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

1 reference

12 December 2020

Sir2 blocks extreme life-span extension.

1 reference

12 December 2020

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

1 reference

12 December 2020

Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

1 reference

12 December 2020

Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.

1 reference

12 December 2020

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

1 reference

12 December 2020

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.

1 reference

12 December 2020

Progressive loss of SIRT1 with cell cycle withdrawal

1 reference

12 December 2020

Lifespan extension in Caenorhabditis elegans by complete removal of food.

1 reference

12 December 2020

Dietary deprivation extends lifespan in Caenorhabditis elegans

1 reference

12 December 2020

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

1 reference

12 December 2020

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

1 reference

12 December 2020

SIRT1 promotes DNA repair activity and deacetylation of Ku70

1 reference

12 December 2020

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

1 reference

12 December 2020

Sirt1 regulates aging and resistance to oxidative stress in the heart

1 reference

12 December 2020

Sirtuins in mammals: insights into their biological function

1 reference

12 December 2020

The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

1 reference

12 December 2020

Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins

1 reference

12 December 2020

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

1 reference

12 December 2020

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

1 reference

12 December 2020

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

1 reference

12 December 2020

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

12 December 2020

A functional link between SIRT1 deacetylase and NBS1 in DNA damage response

1 reference

12 December 2020

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

1 reference

12 December 2020

SirT1 regulates energy metabolism and response to caloric restriction in mice

1 reference

12 December 2020

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

1 reference

12 December 2020

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

1 reference

12 December 2020

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

1 reference

12 December 2020

Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence

1 reference

12 December 2020

Tissue-specific regulation of SIRT1 by calorie restriction

1 reference

12 December 2020

Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells

1 reference

12 December 2020

Life span extension and neuronal cell protection by Drosophila nicotinamidase

1 reference

12 December 2020

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

1 reference

12 December 2020

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

1 reference

12 December 2020

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators

1 reference

12 December 2020

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

1 reference

12 December 2020

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

1 reference

12 December 2020

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

1 reference

12 December 2020

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.

1 reference

12 December 2020

SIRT1 and insulin resistance

1 reference

12 December 2020

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1.

1 reference

12 December 2020

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

1 reference

12 December 2020

Caloric restriction, SIRT1 and longevity

1 reference

12 December 2020

MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.

1 reference

12 December 2020

dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster

1 reference

12 December 2020

The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction

1 reference

12 December 2020

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

1 reference

12 December 2020

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle

1 reference

12 December 2020

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

1 reference

12 December 2020

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

1 reference

12 December 2020

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

1 reference

12 December 2020

Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster

1 reference

12 December 2020

Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

1 reference

12 December 2020

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

1 reference

12 December 2020

3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.

1 reference

12 December 2020

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

1 reference

12 December 2020

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

1 reference

12 December 2020

Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance

1 reference

12 December 2020

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO

1 reference

12 December 2020

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

1 reference

12 December 2020

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

1 reference

12 December 2020

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

1 reference

12 December 2020

SIRT1 is required for long-term growth of human mesenchymal stem cells.

1 reference

12 December 2020

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

1 reference

12 December 2020

SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene.

1 reference

12 December 2020

Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence

1 reference

12 December 2020

SRT1720 improves survival and healthspan of obese mice

1 reference

12 December 2020

The sirtuin SIRT6 regulates lifespan in male mice

1 reference

12 December 2020

Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol

1 reference

12 December 2020

dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies

1 reference

12 December 2020

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

1 reference

12 December 2020

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

1 reference

12 December 2020

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

1 reference

12 December 2020

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

1 reference

12 December 2020

The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent

1 reference

12 December 2020

dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.

1 reference

12 December 2020

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

1 reference

12 December 2020

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

1 reference

12 December 2020

Hydrogen sulfide prevents H₂O₂-induced senescence in human umbilical vein endothelial cells through SIRT1 activation.

1 reference

12 December 2020

Caloric restriction and its mimetics

1 reference

12 December 2020

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

1 reference

12 December 2020

The contentious history of sirtuin debates

1 reference

12 December 2020

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

1 reference

12 December 2020

Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner

1 reference

12 December 2020

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

1 reference

12 December 2020

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

1 reference

12 December 2020

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

1 reference

12 December 2020

The miR-29b-Sirt1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species

1 reference

12 December 2020

Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25-35 in rat cortical neurons

1 reference

12 December 2020

Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway

1 reference

12 December 2020

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

1 reference

12 December 2020

Cellular senescence: from physiology to pathology

1 reference

12 December 2020

The controversial world of sirtuins

1 reference

12 December 2020

Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells

1 reference

12 December 2020

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

1 reference

12 December 2020

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

1 reference

12 December 2020

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases.

1 reference

12 December 2020

The role of sirtuins in aging and age-related diseases.

1 reference

12 December 2020

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

1 reference

12 December 2020

Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status.

1 reference

12 December 2020

Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells.

1 reference

12 December 2020

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

1 reference

12 December 2020

Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster

1 reference

12 December 2020

Sirtuins, a promising target in slowing down the ageing process.

1 reference

12 December 2020

SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation.

1 reference

12 December 2020

Sirtuins, epigenetics and longevity.

1 reference

12 December 2020

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.

1 reference

12 December 2020

Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

1 reference

12 December 2020