(Q64970166)

2 July 2019

title

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer. (English)

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2 July 2019

author name string

Xiaojun Man

1

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2 July 2019

Chiyuan Piao

2

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2 July 2019

Xuyong Lin

3

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2 July 2019

Chuize Kong

4

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2 July 2019

Xiaolu Cui

5

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2 July 2019

Yuanjun Jiang

6

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2 July 2019

publication date

14 June 2019

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2 July 2019

Journal of Experimental & Clinical Cancer Research

published in

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2 July 2019

volume

38

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2 July 2019

issue

1

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2 July 2019

page(s)

259

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2 July 2019

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

cites work

1 reference

12 December 2020

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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12 December 2020

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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12 December 2020

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

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12 December 2020

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

12 December 2020

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma

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12 December 2020

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

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12 December 2020

Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway

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12 December 2020

The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity

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12 December 2020

PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit

1 reference

12 December 2020

NF-kappaB at the crossroads of life and death

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12 December 2020

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

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12 December 2020

Suppression of PTEN expression by NF-kappa B prevents apoptosis

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12 December 2020

Focus on bladder cancer

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12 December 2020

Urothelial tumorigenesis: a tale of divergent pathways

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12 December 2020

Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.

1 reference

12 December 2020

Ubiquitination regulates PTEN nuclear import and tumor suppression

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12 December 2020

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

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12 December 2020

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

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12 December 2020

Post-translational regulation of PTEN.

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12 December 2020

Regulation of MITF stability by the USP13 deubiquitinase

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12 December 2020

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

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12 December 2020

Nongenomic Mechanisms of PTEN Regulation

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12 December 2020

Molecular pathways: next-generation immunotherapy--inhibiting programmed death-ligand 1 and programmed death-1.

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12 December 2020

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12 December 2020

High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral

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12 December 2020

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

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12 December 2020

Deubiquitylation and stabilization of PTEN by USP13

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12 December 2020

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data

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12 December 2020

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

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12 December 2020

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies

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12 December 2020

Improving microRNA target prediction by modeling with unambiguously identified microRNA-target pairs from CLIP-ligation studies

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Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

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12 December 2020

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends.

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12 December 2020

miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expression

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12 December 2020

Amplification of USP13 drives ovarian cancer metabolism

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12 December 2020

A review on the evolution of PD-1/PD-L1 immunotherapy for bladder cancer: The future is now.

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12 December 2020

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

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12 December 2020

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.

1 reference

12 December 2020

The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid

1 reference

12 December 2020

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

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12 December 2020

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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12 December 2020

10.1186/S13046-019-1262-4

Identifiers

DOI

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2 July 2019

PMC publication ID

6570860

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2 July 2019

PubMed publication ID

31200745

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2 July 2019