(Q74298040)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10980615%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

title

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4 (English)

1 reference

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10 November 2019

3

1 reference

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10 November 2019

author name string

Morén A

1

1 reference

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10 November 2019

Itoh S

2

1 reference

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10 November 2019

Dijke P

4

1 reference

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10 November 2019

Heldin CH

5

1 reference

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10 November 2019

language of work or name

English

0 references

publication date

1 September 2000

1 reference

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10 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10980615%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10980615%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

page(s)

4396-4404

1 reference

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10 November 2019

issue

38

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203798

10 November 2019

exact match

0 references

cites work

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

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7 January 2021

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

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7 January 2021

Smads as transcriptional co-modulators

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7 January 2021

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

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7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

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7 January 2021

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

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7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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7 January 2021

Microtubule binding to Smads may regulate TGF beta activity

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

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7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

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7 January 2021

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

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7 January 2021

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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7 January 2021

Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.

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7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

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7 January 2021

Interaction of Smad complexes with tripartite DNA-binding sites

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7 January 2021

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.

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7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

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7 January 2021

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

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7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

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7 January 2021

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

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7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

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7 January 2021

Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

TGF-beta signal transduction

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7 January 2021

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

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7 January 2021

Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes

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7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

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7 January 2021

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

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7 January 2021

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

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7 January 2021

Signaling inputs converge on nuclear effectors in TGF-beta signaling

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7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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7 January 2021

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

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7 January 2021

A Smad transcriptional corepressor

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7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

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7 January 2021

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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7 January 2021

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

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7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

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7 January 2021

Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members.

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

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7 January 2021