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Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop
scientific article published on 01 January 1999
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scholarly article
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
title
Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
main subject
etoposide
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E L Arriola
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1
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
A R Lopez
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2
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
C M Chresta
series ordinal
3
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
language of work or name
English
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publication date
1 January 1999
1 reference
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
published in
Oncogene
1 reference
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
volume
18
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
issue
4
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Europe PubMed Central
PubMed publication ID
10023685
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
page(s)
1081-1091
1 reference
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Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1202391
0 references
cites work
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of mdm-2 and p53 protein in transitional cell carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
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inferred from DOI database lookup
Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
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7 January 2021
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inferred from DOI database lookup
Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
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inferred from DOI database lookup
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
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inferred from DOI database lookup
Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm2 proto-oncogene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fractionation of DNA from mammalian cells by alkaline elution
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered patterns of MDM2 and TP53 expression in human bladder cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 and mdm-2 genes in human testicular germ-cell tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of topoisomerase II-mediated DNA cleavage of the c-myc gene during HL60 differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of Mdm2 and enhancement of cell survival by bFGF.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage induces phosphorylation of the amino terminus of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppressor genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 binds to a constitutively nucleosome free region of the mdm2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the retinoblastoma protein and the oncoprotein MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202391
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1202391
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
Dimensions Publication ID
1043946134
0 references
PubMed publication ID
10023685
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10023685
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023685%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
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