(Q78666553)

English

Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR

scientific article published on 01 December 2002

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483527%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483527%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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Steve H Kim

1

1 reference

Europe PubMed Central

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15 December 2019

Shobha Gunnery

2

1 reference

Europe PubMed Central

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15 December 2019

Jin K Choe

3

1 reference

Europe PubMed Central

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15 December 2019

Michael B Mathews

4

1 reference

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15 December 2019

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publication date

1 December 2002

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Europe PubMed Central

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15 December 2019

1 reference

Europe PubMed Central

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15 December 2019

21

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15 December 2019

57

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Europe PubMed Central

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15 December 2019

8741-8748

1 reference

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15 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205987

0 references

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

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Host defense, viruses and apoptosis

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Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

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Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells

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Translational control: the cancer connection

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Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein

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Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

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Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.

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7 January 2021

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Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma

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Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region

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Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues.

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Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma.

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7 January 2021

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Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.

1 reference

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7 January 2021

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PKR, apoptosis and cancer

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The interferon system: a review with emphasis on the role of PKR in growth control

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Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

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Lessons from hereditary colorectal cancer

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Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

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7 January 2021

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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The machine that decodes the genome

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

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Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.

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Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF-2B

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Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group

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7 January 2021

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PKR: a new name and new roles.

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Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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Antiviral actions of interferons

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Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells

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c-Myc is a major mediator of the synergistic growth inhibitory effects of retinoic acid and interferon in breast cancer cells

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Expression of p68 in human colon cancer.

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Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B.

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Protein expression of double-stranded RNA-activated protein kinase in thyroid carcinomas: correlations with histologic types, pathologic parameters, and Ki-67 labeling

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Protein expression of double-stranded RNA-activated protein kinase (PKR) in intrahepatic bile ducts in normal adult livers, fetal livers, primary biliary cirrhosis, hepatolithiasis and intrahepatic cholangiocarcinoma

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PKR; a sentinel kinase for cellular stress

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Signal integration via PKR.

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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

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Cell cycle regulation of the double stranded RNA activated protein kinase, PKR

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NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

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