(Q80149163)

English

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

scientific article published on 21 August 2006

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scholarly article

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Europe PubMed Central

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29 December 2019

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation (English)

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29 December 2019

author name string

Takada Y

1

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29 December 2019

Ichikawa H

2

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29 December 2019

Pataer A

3

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29 December 2019

Swisher S

4

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29 December 2019

Aggarwal BB

5

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29 December 2019

publication date

21 August 2006

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29 December 2019

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29 December 2019

26

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29 December 2019

8

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29 December 2019

1201-1212

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29 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209906

0 references

Signalling pathways of the TNF superfamily: a double-edged sword

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Nuclear factor-kappaB: the enemy within

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Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

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Induction of E-Selectin Expression by Double-Stranded RNA and TNF- Is Attenuated in Murine Aortic Endothelial Cells Derived from Double-Stranded RNA-Activated Kinase (PKR)-Null Mice

1 reference

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

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Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells

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Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

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The protein kinase PKR: a molecular clock that sequentially activates survival and death programs

1 reference

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Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

1 reference

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Missing pieces in the NF-kappaB puzzle

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

1 reference

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7 January 2021

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TRAF family proteins link PKR with NF-kappa B activation

1 reference

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The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.

1 reference

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Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?

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7 January 2021

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The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

1 reference

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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7 January 2021

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways.

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Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.

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Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase

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RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

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Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages

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Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

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Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction

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Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

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Modular structure of PACT: distinct domains for binding and activating PKR

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Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons

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Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

1 reference

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Mechanisms by which IkappaB proteins control NF-kappaB activity

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Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

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Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor

1 reference

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1 reference

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1 reference

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1 reference

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Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

1 reference

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7 January 2021

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IkappaB kinase: beginning, not the end

1 reference

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7 January 2021

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Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1 reference

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7 January 2021

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The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

1 reference

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7 January 2021

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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

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7 January 2021

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Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells

1 reference

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7 January 2021

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An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

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1 reference

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NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

1 reference

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

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