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Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells
scientific article published on 31 January 2008
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
title
Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
main subject
apoptotic process
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based on heuristic
inferred from title
author
Martin Dyer
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
author name string
S Inoue
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
R Walewska
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
G M Cohen
series ordinal
4
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Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
publication date
31 January 2008
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
published in
Leukemia
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
volume
22
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
issue
4
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Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
page(s)
819-825
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/leu.2008.1
0 references
cites work
Cell death: critical control points
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Bcl-2 apoptotic switch in cancer development and therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-Only proteins-essential initiators of apoptotic cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The triterpenoid CDDO induces apoptosis in refractory CLL B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mcl-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myeloid cell leukemia-1 as a therapeutic target
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone deacetylase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone deacetylase inhibitors: insights into mechanisms of lethality
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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Inhibition of Histone Deacetylase Class I but not Class II Is Critical for the Sensitization of Leukemic Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis
1 reference
stated in
Crossref
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7 January 2021
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Naphthyl ketones: a new class of Janus kinase 3 inhibitors
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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inferred from DOI database lookup
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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inferred from DOI database lookup
Fold up or perish: unfolded protein response and chemotherapy
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Structural insights into the degradation of Mcl-1 induced by BH3 domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting multiple arms of the apoptotic regulatory machinery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinase pathways as targets for cancer treatment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
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inferred from DOI database lookup
Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
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7 January 2021
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inferred from DOI database lookup
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
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Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FLEU.2008.1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/LEU.2008.1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
Dimensions Publication ID
1025778624
0 references
PubMed publication ID
18239621
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18239621
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18239621%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 January 2020
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