(Q80665120)

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Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis

scientific article published on 31 December 2007

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2 January 2020

Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis (English)

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Irmgard Merfort

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Frank Götschel

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Claudia Kern

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Simona Lang

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Titus Sparna

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Cordula Markmann

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Joseph Schwager

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Sabine McNelly

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Fritz von Weizsäcker

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Experimental Cell Research

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2 January 2020

GSK-3: tricks of the trade for a multi-tasking kinase

1 reference

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Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.

1 reference

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Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes

1 reference

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Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor

1 reference

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7 January 2021

Transcriptional regulation via the NF-kappaB signaling module.

1 reference

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7 January 2021

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

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7 January 2021

Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription

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Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.

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Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein.

1 reference

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Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

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Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

1 reference

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7 January 2021

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration

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7 January 2021

Liver regeneration: from myth to mechanism

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7 January 2021

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.

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Epigallocatechin-3-gallate impairs chemokine production in human colon epithelial cell lines

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

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7 January 2021

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro

1 reference

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7 January 2021

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

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7 January 2021

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

1 reference

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7 January 2021

Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin

1 reference

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7 January 2021

Wnt/beta-catenin signaling in development and disease

1 reference

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7 January 2021

Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway

1 reference

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7 January 2021

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1 reference

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7 January 2021

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase

1 reference

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7 January 2021

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

1 reference

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7 January 2021

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

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7 January 2021

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

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7 January 2021

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

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Tumor necrosis factor signaling.

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NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages

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Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

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Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation

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Functions of c-Jun in liver and heart development

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c-Jun is essential for normal mouse development and hepatogenesis

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A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture

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Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL

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Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18261723%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18261723%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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