(Q40265640)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1

1 reference

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25 December 2019

author name string

Kwang Seok Ahn

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Santosh K Sandur

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Xin Lin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Madan M Chaturvedi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Bharat B Aggarwal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

19 June 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

25 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

23425-23435

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

25 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin, a Chinese anti-leukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

GSK-3-selective inhibitors derived from Tyrian purple indirubins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Nuclear factor-kappaB: the enemy within

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Nuclear transcription factor-kappaB as a target for cancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Missing pieces in the NF-kappaB puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Mechanisms by which IkappaB proteins control NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

The essential role of MEKK3 in TNF-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Activation of IkappaB kinase beta by protein kinase C isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602627200

21 January 2018

Identifiers

DOI

10.1074/JBC.M602627200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16785236%20AND%20SRC:MED&resulttype=core&format=json

release_nxsih3emdbacnia56trawb2ho4

25 December 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nxsih3emdbacnia56trawb2ho4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference