(Q80946687)

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Integrin activation

scientific article published on 01 April 2008

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scholarly article

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4 January 2020

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Integrin activation (English)

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4 January 2020

author name string

Asoka Banno

1

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4 January 2020

Mark H Ginsberg

2

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publication date

1 April 2008

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4 January 2020

Biochemical Society Transactions

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4 January 2020

36

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4 January 2020

229-234

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4 January 2020

Pt 2

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4 January 2020

Integrin activation--the importance of a positive feedback.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras GTPases: integrins' friends or foes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linking Rap to cell adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of integrin activation by talin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function and interactions of integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphotyrosine binding-like domain of talin activates integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focal adhesions - the cytoskeletal connection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin structure, allostery, and bidirectional signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tests of the extension and deadbolt models of integrin activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of integrin recognition by talin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence and domain structure of talin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The talin-tail interaction places integrin activation on FERM ground

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrins: bidirectional, allosteric signaling machines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane signal transduction of the alpha(IIb)beta(3) integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for talin during alpha(M)beta(2)-mediated phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin activation takes shape

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the structural basis of integrin activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin cytoplasmic domains mediate inside-out signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin bidirectional signaling: a molecular view

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inner world of cell adhesion: integrin cytoplasmic domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of integrin regulation and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin structures and conformational signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-mediated proteolysis of talin regulates adhesion dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Integrin αIIbβ3Activation by Distinct Regions of Its Cytoplasmic Tails†

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific interface between integrin transmembrane helices and affinity for ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18363565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BST0360229

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18363565%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18363565%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18363565%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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