(Q82857959)

English

Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

scientific article published on 16 March 2006

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scholarly article

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Europe PubMed Central

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18 January 2020

Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle (English)

1 reference

Europe PubMed Central

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18 January 2020

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author name string

David L Williamson

1

1 reference

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18 January 2020

Neil Kubica

2

1 reference

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18 January 2020

Scot R Kimball

3

1 reference

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18 January 2020

Leonard S Jefferson

4

1 reference

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18 January 2020

publication date

16 March 2006

1 reference

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18 January 2020

Journal of Physiology

1 reference

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18 January 2020

573

1 reference

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18 January 2020

Pt 2

1 reference

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18 January 2020

497-510

1 reference

Europe PubMed Central

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18 January 2020

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular mechanics of eukaryotic translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream and downstream of mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon and plasma catecholamine responses to graded and prolonged exercise in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of beta-blockade on glycogen metabolism in human subjects during exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensity and duration of exercise effects on skeletal muscle cAMP, phosphorylase, and glycogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of 40S ribosomal protein S6 phosphorylation during the mitogenic response

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP levels in fast- and slow-twitch skeletal muscle after an acute bout of aerobic exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb binds and regulates the mTOR kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16543272

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1113/JPHYSIOL.2005.103481

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16543272%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16543272%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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