(Q83274402)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22257149%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Drug interactions with herbal medicines (English)

1 reference

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20 January 2020

author name string

Shaojun Shi

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22257149%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Ulrich Klotz

series ordinal

2

1 reference

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20 January 2020

publication date

1 February 2012

1 reference

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Clinical Pharmacokinetics

20 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22257149%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22257149%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

2

1 reference

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20 January 2020

page(s)

77-104

1 reference

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https://scigraph.springernature.com/pub.10.2165/11597910-000000000-00000

20 January 2020

exact match

0 references

cites work

Use of herbal products and potential interactions in patients with cardiovascular diseases

1 reference

12 December 2020

Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats

1 reference

12 December 2020

Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use.

1 reference

12 December 2020

High dose of commercial products of kava (Piper methysticum) markedly enhanced hepatic cytochrome P450 1A1 mRNA expression with liver enlargement in rats

1 reference

12 December 2020

An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents.

1 reference

12 December 2020

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

1 reference

12 December 2020

The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level.

1 reference

12 December 2020

The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol

1 reference

12 December 2020

The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone

1 reference

12 December 2020

St John's wort-associated drug interactions: short-term inhibition and long-term induction?

1 reference

12 December 2020

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

1 reference

12 December 2020

Effect of St John's wort dose and preparations on the pharmacokinetics of digoxin

1 reference

12 December 2020

Studies on interactions between functional foods or dietary supplements and medicines. III. Effects of ginkgo biloba leaf extract on the pharmacokinetics of nifedipine in rats

1 reference

12 December 2020

Clinically based evidence of drug-herb interactions: a systematic review

1 reference

12 December 2020

Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding

1 reference

12 December 2020

Molecular mechanisms underlying St. John's wort drug interactions

1 reference

12 December 2020

The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices

1 reference

12 December 2020

Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial.

1 reference

12 December 2020

Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): critical analysis and structured causality assessment

1 reference

12 December 2020

Methadone maintenance treatment and St. John's Wort - a case report

1 reference

12 December 2020

Herb-drug pharmacokinetic interactions reviewed.

1 reference

12 December 2020

Probable interaction between warfarin and ginseng

1 reference

12 December 2020

Long-term effects of Panax ginseng on disposition of fexofenadine in rats in vivo

1 reference

12 December 2020

Aged garlic extract stimulates p-glycoprotein and multidrug resistance associated protein 2 mediated effluxes

1 reference

12 December 2020

A critical evaluation of drug interactions with Echinacea spp.

1 reference

12 December 2020

Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity

1 reference

12 December 2020

Chemical and pharmacological studies of saponins with a focus on American ginseng

1 reference

12 December 2020

Mechanisms of cytochrome P450 induction

1 reference

12 December 2020

Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats

1 reference

12 December 2020

Drug interaction of herbal tea containing St. John's wort with cyclosporine

1 reference

12 December 2020

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

1 reference

12 December 2020

Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial

1 reference

12 December 2020

Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial

1 reference

12 December 2020

The extent of induction of CYP3A by St. John's wort varies among products and is linked to hyperforin dose.

1 reference

12 December 2020

Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations

1 reference

12 December 2020

The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate

1 reference

12 December 2020

Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro

1 reference

12 December 2020

Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes

1 reference

12 December 2020

P-Glycoprotein inhibitory activity of lipophilic constituents of Echinacea pallida roots in a human proximal tubular cell line

1 reference

12 December 2020

The interaction between St John's wort and an oral contraceptive

1 reference

12 December 2020

Inhibition of human cytochrome P450 activities by kava extract and kavalactones

1 reference

12 December 2020

In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition

1 reference

12 December 2020

Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment

1 reference

12 December 2020

Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity

1 reference

12 December 2020

Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects

1 reference

12 December 2020

Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro

1 reference

12 December 2020

Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes

1 reference

12 December 2020

Pharmacodynamic interaction of garlic with propranolol in ischemia-reperfusion induced myocardial damage.

1 reference

12 December 2020

Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer

1 reference

12 December 2020

Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression

1 reference

12 December 2020

St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

1 reference

12 December 2020

Potential metabolic interaction between St. John's wort and theophylline

1 reference

12 December 2020

Does St. John's wort interfere with the antiandrogenic effect of oral contraceptive pills?

1 reference

12 December 2020

Echinacea purpurea and P-glycoprotein drug transport in Caco-2 cells

1 reference

12 December 2020

Herbal product-drug interactions mediated by induction

1 reference

12 December 2020

Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.

1 reference

12 December 2020

The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes

1 reference

12 December 2020

Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats

1 reference

12 December 2020

Pregnane X receptor-mediated induction of Cyp3a by black cohosh

1 reference

12 December 2020

St John's wort modulation and developmental expression of multidrug transporters in the rat.

1 reference

12 December 2020

Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time

1 reference

12 December 2020

Effect of St. John's wort on the pharmacokinetics of theophylline in healthy volunteers

1 reference

12 December 2020

Drug interactions with herbal medicines

1 reference

12 December 2020

Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients

1 reference

12 December 2020

Potential of pharmacokinetic profiling for detecting herbal interactions with drugs

1 reference

12 December 2020

Isolation and analysis of ginseng: advances and challenges

1 reference

12 December 2020

Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells

1 reference

12 December 2020

Interactions between herbal remedies and medicinal drugs--considerations about Cuba

1 reference

12 December 2020

Garlic (Allium sativum L.): adverse effects and drug interactions in humans

1 reference

12 December 2020

Hyperforin in St. John's wort drug interactions

1 reference

12 December 2020

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

1 reference

12 December 2020

In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity

1 reference

12 December 2020

The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial

1 reference

12 December 2020

Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical review

1 reference

12 December 2020

Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9.

1 reference

12 December 2020

Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

1 reference

12 December 2020

Effect of several Chinese natural health products of human cytochrome P450 metabolism

1 reference

12 December 2020

In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

1 reference

12 December 2020

Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers

1 reference

12 December 2020

Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers

1 reference

12 December 2020

Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers.

1 reference

12 December 2020

The effect of garlic on cyclosporine-A-induced hyperlipidemia in male rats

1 reference

12 December 2020

St. John's wort: role of active compounds for its mechanism of action and efficacy

1 reference

12 December 2020

No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.

1 reference

12 December 2020

Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract

1 reference

12 December 2020

In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products

1 reference

12 December 2020

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

1 reference

12 December 2020

Drug interactions with St. John's wort products

1 reference

12 December 2020

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes

1 reference

12 December 2020

Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide

1 reference

12 December 2020

Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats

1 reference

12 December 2020

Black grape and garlic extracts protect against cyclosporine a nephrotoxicity

1 reference

12 December 2020

Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

1 reference

12 December 2020

Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers.

1 reference

12 December 2020

Different effects of St John's wort on the pharmacokinetics of simvastatin and pravastatin

1 reference

12 December 2020

United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity

1 reference

12 December 2020

Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females

1 reference

12 December 2020

Milk thistle in liver diseases: past, present, future

1 reference

12 December 2020

Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan

1 reference

12 December 2020

Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial

1 reference

12 December 2020

Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus

1 reference

12 December 2020

Molecular mechanisms of cytochrome p450 induction: potential for drug-drug interactions

1 reference

12 December 2020

Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.

1 reference

12 December 2020

The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers

1 reference

12 December 2020

Evidence-based drug--herbal interactions

1 reference

12 December 2020

Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes

1 reference

12 December 2020

Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole

1 reference

12 December 2020

Effects of St. John's wort extract on indinavir pharmacokinetics in rats: differentiation of intestinal and hepatic impacts.

1 reference

12 December 2020

Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects

1 reference

12 December 2020

Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis

1 reference

12 December 2020

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study

1 reference

12 December 2020

Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients

1 reference

12 December 2020

Insilico studies of organosulfur-functional active compounds in garlic

1 reference

12 December 2020

Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes

1 reference

12 December 2020

Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme

1 reference

12 December 2020

Long-term efficacy of Serenoa repens treatment in patients with mild and moderate symptomatic benign prostatic hyperplasia.

1 reference

12 December 2020

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans

1 reference

12 December 2020

Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein

1 reference

12 December 2020

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures

1 reference

12 December 2020

Pharmacovigilance: effects of herbal components on human drugs interactions involving cytochrome P450

1 reference

12 December 2020

Garlic interaction with fluindione: a case report.

1 reference

12 December 2020

The effect of St John's wort extracts on CYP3A: a systematic review of prospective clinical trials

1 reference

12 December 2020

Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

1 reference

12 December 2020

The effect of silymarin on oral nifedipine pharmacokinetics

1 reference

12 December 2020

Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers.

1 reference

12 December 2020

Echinacea for treating the common cold: a randomized trial

1 reference

12 December 2020

Induction of imatinib metabolism by hypericum perforatum

1 reference

12 December 2020

St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: a 30-day ingestion study

1 reference

12 December 2020

Modulation of P-glycoprotein function by St John's wort extract and its major constituents

1 reference

12 December 2020

Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits

1 reference

12 December 2020

Scientific and regulatory perspectives on metabolizing enzyme-transporter interplay and its role in drug interactions: challenges in predicting drug interactions

1 reference

12 December 2020

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B.

1 reference

12 December 2020

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate

1 reference

12 December 2020

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity

1 reference

12 December 2020

Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers

1 reference

12 December 2020

St John's wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive

1 reference

12 December 2020

St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier

1 reference

12 December 2020

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

1 reference

12 December 2020

Review article: cytochrome P450 enzyme, and transport protein mediated herb-drug interactions in renal transplant patients: grapefruit juice, St John's Wort - and beyond!

1 reference

12 December 2020

Echinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjects

1 reference

12 December 2020

Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics

1 reference

12 December 2020

Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats.

1 reference

12 December 2020

St. John's wort: effect on CYP2D6 activity using dextromethorphan-dextrorphan ratios

1 reference

12 December 2020

Effect of silymarin supplement on the pharmacokinetics of rosuvastatin

1 reference

12 December 2020

St John's wort (Hypericum perforatum) in major depression

1 reference

12 December 2020

Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4

1 reference

12 December 2020

Effects of herbal products and their constituents on human cytochrome P450(2E1) activity

1 reference

12 December 2020

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men.

1 reference

12 December 2020

Potential of St John's Wort for the treatment of depression: the economic perspective.

1 reference

12 December 2020

Impact of ginkgo biloba on the pharmacokinetics of digoxin.

1 reference

12 December 2020

Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel

1 reference

12 December 2020

Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

1 reference

12 December 2020

Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans

1 reference

12 December 2020

The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil

1 reference

12 December 2020

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

1 reference

12 December 2020

Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius

1 reference

12 December 2020

Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin

1 reference

12 December 2020

Herbal and dietary supplement--drug interactions in patients with chronic illnesses.

1 reference

12 December 2020

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations

1 reference

12 December 2020

Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis

1 reference

12 December 2020

Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats

1 reference

12 December 2020

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

1 reference

12 December 2020

Drug interaction between St John's wort and zolpidem in healthy subjects

1 reference

12 December 2020

Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers

1 reference

12 December 2020

The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers

1 reference

12 December 2020

Interaction between a commercially available St. John's wort product (Movina) and atorvastatin in patients with hypercholesterolemia.

1 reference

12 December 2020

In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients

1 reference

12 December 2020

Lack of pharmacokinetic interaction between St. John's wort and prednisone

1 reference

12 December 2020

Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir

1 reference

12 December 2020

Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

1 reference

12 December 2020

The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide

1 reference

12 December 2020

Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats.

1 reference

12 December 2020

Effects of dietary chemopreventive phytochemicals on P-glycoprotein function

1 reference

12 December 2020

Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril.

1 reference

12 December 2020

Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers

1 reference

12 December 2020

Herbal bioactivation: the good, the bad and the ugly

1 reference

12 December 2020

Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaboration.

1 reference

12 December 2020

Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content

1 reference

12 December 2020

Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

1 reference

12 December 2020

An update on clinical drug interactions with the herbal antidepressant St. John's wort

1 reference

12 December 2020

The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo

1 reference

12 December 2020

HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy

1 reference

12 December 2020

Pharmacodynamic interaction of garlic with hydrochlorothiazide in rats.

1 reference

12 December 2020

Long-term feeding of Ginkgo biloba extract impairs peripheral circulation and hepatic function in aged spontaneously hypertensive rats

1 reference

12 December 2020

Effect of St John's wort on imatinib mesylate pharmacokinetics

1 reference

12 December 2020

In vitro interactions of water-soluble garlic components with human cytochromes p450

1 reference

12 December 2020

Drug-drug interactions of silymarin on the perspective of pharmacokinetics

1 reference

12 December 2020

In vitro and in vivo assessment of herb drug interactions

1 reference

12 December 2020

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

1 reference

12 December 2020

Risk of kava hepatotoxicity and the FDA consumer advisory

1 reference

12 December 2020

Interaction between warfarin and Panax ginseng in ischemic stroke patients

1 reference

12 December 2020

Haemorrhage due to Ginkgo biloba?

1 reference

12 December 2020

Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse

1 reference

12 December 2020

Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo

1 reference

12 December 2020

Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir

1 reference

12 December 2020

Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba

1 reference

12 December 2020

Summaries for patients. Ginseng reduces the effect of warfarin in a study of healthy volunteers

1 reference

12 December 2020

Interactions between drugs and four common medicinal herbs

1 reference

12 December 2020

Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers

1 reference

12 December 2020

Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers

1 reference

12 December 2020

Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products

1 reference

12 December 2020

Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.

1 reference

12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

1 reference

12 December 2020

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

1 reference

12 December 2020

No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract

1 reference

12 December 2020

Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro

1 reference

12 December 2020

The recovery time-course of CYP3A after induction by St John's wort administration

1 reference

12 December 2020

Kava: a comprehensive review of efficacy, safety, and psychopharmacology

1 reference

12 December 2020

The drug transporter-metabolism alliance: uncovering and defining the interplay

1 reference

12 December 2020

Ginsenosides from American ginseng: chemical and pharmacological diversity

1 reference

12 December 2020

Assessment of drug-drug interaction for silymarin

1 reference

12 December 2020

Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients

1 reference

12 December 2020

Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.

1 reference

12 December 2020

Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort

1 reference

12 December 2020

Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.

1 reference

12 December 2020

Predicting interactions between conventional medications and botanical products on the basis of in vitro investigations

1 reference

12 December 2020

ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions

1 reference

12 December 2020

Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract

1 reference

12 December 2020

Clinical drugs that interact with St. John's wort and implication in drug development

1 reference

12 December 2020

Multiple-Dose Administration of Ginkgo biloba Did Not Affect Cytochrome P-450 2D6 or 3A4 Activity in Normal Volunteers

1 reference

12 December 2020

The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.

1 reference

12 December 2020

Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

1 reference

12 December 2020

St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse

1 reference

12 December 2020

Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities

1 reference

12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

1 reference

12 December 2020

The clinical implications of ageing for rational drug therapy

1 reference

12 December 2020

The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activity

1 reference

12 December 2020

Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity

1 reference

12 December 2020

The effect of garlic extract on human metabolism of acetaminophen

1 reference

12 December 2020

Serenoa repens (saw palmetto): a systematic review of adverse events

1 reference

12 December 2020

Study on the influence of silymarin pretreatment on metabolism and disposition of metronidazole

1 reference

12 December 2020

Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats

1 reference

12 December 2020

Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes

1 reference

12 December 2020

Pharmacodynamic interaction of captopril with garlic in isoproterenol-induced myocardial damage in rat.

1 reference

12 December 2020

Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans

1 reference

12 December 2020

Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4).

1 reference

12 December 2020

Pharmacokinetic drug interactions by herbal drugs: Critical evaluation and clinical relevance

1 reference

12 December 2020

Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats

1 reference

12 December 2020

Herbal supplements and therapeutic drug monitoring: focus on digoxin immunoassays and interactions with St. John's wort

1 reference

12 December 2020

Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis

1 reference

12 December 2020

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

1 reference

12 December 2020

Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers

1 reference

12 December 2020

Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity

1 reference

12 December 2020

Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver

1 reference

12 December 2020

Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

1 reference

12 December 2020

Comparison of the pharmacokinetics of ticlopidine between administration of a combined fixed-dose tablet formulation of ticlopidine 250 mg/ginkgo extract 80 mg, and concomitant administration of ticlopidine 250-mg and ginkgo extract 80-mg tablets: a

1 reference

12 December 2020

Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes

1 reference

12 December 2020

Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence?

1 reference

12 December 2020

Transporter-mediated drug interactions: clinical implications and in vitro assessment

1 reference

12 December 2020

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

1 reference

12 December 2020

Potential drug-herb interaction with antiplatelet/anticoagulant drugs

1 reference

12 December 2020

Pharmacokinetic interaction between oltipraz and silymarin in rats.

1 reference

12 December 2020

Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement

1 reference

12 December 2020

Inhibition and induction of human cytochrome P450 enzymes: current status

1 reference

12 December 2020

Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects

1 reference

12 December 2020

Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study

1 reference

12 December 2020

Induction of cytochrome P450s by terpene trilactones and flavonoids of theGinkgo bilobaextract EGb 761 in rats

1 reference

12 December 2020

Effects of St. John's wort on irinotecan metabolism

1 reference

12 December 2020

Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin

1 reference

12 December 2020

An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic

1 reference

12 December 2020

Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp

1 reference

12 December 2020

The potential for interaction of hydrochlorothiazide with garlic in rats.

1 reference

12 December 2020

Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers

1 reference

12 December 2020

Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers

1 reference

12 December 2020

Herb-drug interactions: a literature review

1 reference

12 December 2020

Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme

1 reference

12 December 2020

Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells

1 reference

12 December 2020

Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers

1 reference

12 December 2020

Possible serotonin syndrome after combination of buspirone and St John's Wort

1 reference

12 December 2020

Interaction of St John's wort with low‐dose oral contraceptive therapy: a randomized controlled trial

1 reference

12 December 2020

Inhibition of human cytochromes P450 by components of Ginkgo biloba

1 reference

12 December 2020

Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?

1 reference

12 December 2020

In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1.

1 reference

12 December 2020

In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products

1 reference

12 December 2020

Coma from the health food store: interaction between kava and alprazolam

1 reference

12 December 2020

Traditional aqueous kava extracts inhibit cytochrome P450 1A2 in humans: Protective effect against environmental carcinogens?

1 reference

12 December 2020

Drug interaction between St John's Wort and quazepam.

1 reference

12 December 2020

Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytes.

1 reference

12 December 2020

Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition

1 reference

12 December 2020

Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats

1 reference

12 December 2020

Lack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizers

1 reference

12 December 2020

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

1 reference

12 December 2020

St. John's wort found to lower nevirapine levels

1 reference

12 December 2020

Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes

1 reference

12 December 2020

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures

1 reference

12 December 2020

The influence of St John's Wort on CYP2C19 activity with respect to genotype

1 reference

12 December 2020

Interactions between herbal medicines and prescribed drugs: an updated systematic review

1 reference

12 December 2020

Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs

1 reference

12 December 2020

Screening of organosulfur compounds as inhibitors of human CYP2A6

1 reference

12 December 2020

Interactions between Natural Health Products and Oral Anticoagulants: Spontaneous Reports in the Italian Surveillance System of Natural Health Products

1 reference

12 December 2020

Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).

1 reference

12 December 2020

Influence of Goldenseal Root on the Pharmacokinetics of Indinavir

1 reference

12 December 2020

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

1 reference

12 December 2020

Drug interaction between St John's wort and nevirapine

1 reference

12 December 2020

Coadministration of milk thistle and indinavir in healthy subjects

1 reference

12 December 2020

Pharmacokinetics and drug metabolism in the elderly

1 reference

12 December 2020

The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats

1 reference

12 December 2020

Kava and dopamine antagonism

1 reference

12 December 2020

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line

1 reference

12 December 2020

The elderly--a challenge for appropriate drug treatment

1 reference

12 December 2020

[Herbal drug-drug interaction and adverse drug reactions]

1 reference

12 December 2020

The effect of garlic supplements on the pharmacokinetics of saquinavir

1 reference

12 December 2020

Effects of St. John's wort (Hypericum perforatum) on tacrolimus pharmacokinetics in healthy volunteers

1 reference

12 December 2020

Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo.

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects

1 reference

12 December 2020

Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.

1 reference

12 December 2020

Herb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patients

1 reference

12 December 2020

Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol

1 reference

12 December 2020

MDR- and CYP3A4-mediated drug-herbal interactions

1 reference

12 December 2020

Aged garlic extract may be safe for patients on warfarin therapy

1 reference

12 December 2020

Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.

1 reference

12 December 2020

Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats

1 reference

12 December 2020

Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition

1 reference

12 December 2020

Effects of Ginkgo biloba in dementia: systematic review and meta-analysis

1 reference

12 December 2020

Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components

1 reference

12 December 2020

Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?

1 reference

12 December 2020

Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver.

1 reference

12 December 2020

Influence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: an open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers

1 reference

12 December 2020

Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects

1 reference

12 December 2020

Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in renal transplant recipients.

1 reference

12 December 2020

Cytochrome P450 enzyme isoforms and their therapeutic implications: an update.

1 reference

12 December 2020

Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?

1 reference

12 December 2020

Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats

1 reference

12 December 2020

Effect of St. John's wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers

1 reference

12 December 2020

St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1.

1 reference

12 December 2020

CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations

1 reference

12 December 2020

Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract

1 reference

12 December 2020

Indinavir concentrations and St John's wort.

1 reference

12 December 2020

Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.

1 reference

12 December 2020

Interaction study on garlic and atorvastatin with reference to nephrotoxicity in dyslipidaemic rats

1 reference

12 December 2020

Effects of St. John's wort supplementation on ibuprofen pharmacokinetics

1 reference

12 December 2020

Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells

1 reference

12 December 2020

Serotonin syndrome and rhabdomyolysis induced by concomitant use of triptans, fluoxetine and hypericum

1 reference

12 December 2020