(Q84315461)

English

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

scientific article published in September 2019

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scholarly article

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Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase (English)

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Emerging viruses

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Mark R. Denison

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object named as

Mark R Denison

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Timothy P Sheahan

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object named as

Timothy P Sheahan

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9

object named as

Ralph S Baric

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Tomáš Cihlář

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object named as

Tomas Cihlar

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Ariane J. Brown

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object named as

Ariane J Brown

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Rachel L. Graham

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object named as

Rachel L Graham

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object named as

Amy C Sims

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Kenneth H Dinnon Iii

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object named as

Kenneth H Dinnon

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Joy Y Feng

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author name string

John J Won

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language of work or name

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publication date

September 2019

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Antiviral Research

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169

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104541

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Uptake properties of lamivudine (3TC) by a continuous renal epithelial cell line

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Rhinovirus and coronavirus infection-associated hospitalizations among older adults.

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Human respiratory coronavirus OC43: genetic stability and neuroinvasion

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Development of a transgenic mouse model susceptible to human coronavirus 229E.

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Performance of different mono- and multiplex nucleic acid amplification tests on a multipathogen external quality assessment panel

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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The dominance of human coronavirus OC43 and NL63 infections in infants

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Evidence supporting a zoonotic origin of human coronavirus strain NL63

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Clinical impact of human coronaviruses 229E and OC43 infection in diverse adult populations

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Bat origin of human coronaviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Coronaviruses - drug discovery and therapeutic options.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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SARS-like WIV1-CoV poised for human emergence

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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SARS and MERS: recent insights into emerging coronaviruses

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

based on heuristic

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Epidemiology and Clinical Features of Human Coronaviruses in the Pediatric Population

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

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https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

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Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

based on heuristic

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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

based on heuristic

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Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31233808

12 December 2020

based on heuristic

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Identifiers

10.1016/J.ANTIVIRAL.2019.104541

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PubMed publication ID

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