(Q84372988)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors (English)

1 reference

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5 February 2020

author name string

Ganesan Karthikeyan

1

1 reference

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5 February 2020

Claudio Zambaldo

2

1 reference

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5 February 2020

Sofia Barluenga

3

1 reference

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5 February 2020

Vincent Zoete

4

1 reference

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5 February 2020

publication date

13 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696415%20AND%20SRC:MED&resulttype=core&format=json

Chemistry—A European Journal

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

18

1 reference

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5 February 2020

issue

29

1 reference

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5 February 2020

page(s)

8978-8986

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696415%20AND%20SRC:MED&resulttype=core&format=json

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

5 February 2020

cites work

1 reference

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Lewis base activation of Lewis acids: catalytic, enantioselective addition of silyl ketene acetals to aldehydes

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Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

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Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus

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Pochonins K–P: new radicicol analogues from Pochonia chlamydosporia var. chlamydosporia and their WNT-5A expression inhibitory activities

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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Hsp90 inhibition with resorcyclic acid lactones (RALs).

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The search for a hair-growth stimulant: new radicicol analogues as WNT-5A expression inhibitors from Pochonia chlamydosporia var. chlamydosporia

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The development of L2X2Ru=CHR olefin metathesis catalysts: an organometallic success story

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Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

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HSP90 and the chaperoning of cancer

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Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands

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11 October 2022

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A New Antifungal Substance of Fungal Origin

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11 October 2022

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Molecular chaperones in protein folding and proteostasis

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11 October 2022

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The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts

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11 October 2022

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Lewis base activation of Lewis acids. Vinylogous aldol addition reactions of conjugated N,O-silyl ketene acetals to aldehydes

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11 October 2022

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Inhibition of HSP90 with pochoximes: SAR and structure-based insights

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11 October 2022

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Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells

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11 October 2022

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Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

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11 October 2022

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Heat shock protein 90: inhibitors in clinical trials.

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11 October 2022

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Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

1 reference

11 October 2022

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The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

1 reference

11 October 2022

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Chemistry and biology of resorcylic acid lactones

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

1 reference

11 October 2022

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Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

1 reference

11 October 2022

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

1 reference

11 October 2022

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

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11 October 2022

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Blind docking of 260 protein-ligand complexes with EADock 2.0.

1 reference

11 October 2022

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Concise synthesis of pochonin A, an HSP90 inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

1 reference

11 October 2022

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Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Synthesis of the purported ent-pochonin J structure featuring a stereoselective oxocarbenium allylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases

1 reference

11 October 2022

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Modular asymmetric synthesis of pochonin C

1 reference

11 October 2022

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Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata

1 reference

11 October 2022

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Nematicidal resorcylides from the aquatic fungus Caryospora callicarpa YMF1.01026.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Lewis base activation of Lewis acids: catalytic, enantioselective vinylogous aldol addition reactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Heat shock protein 90 in neurodegenerative diseases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Lewis base activation of Lewis acids. Vinylogous aldol reactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Targeting Hsp90: small-molecule inhibitors and their clinical development

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.201200546

Identifiers

DOI

10.1002/CHEM.201200546

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22696415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference