(Q88817029)

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Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

scientific article published on 31 May 2017

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scholarly article

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27 March 2020

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making (English)

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27 March 2020

decision making

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Kenneth Offit

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27 March 2020

Philip W. Kantoff

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object named as

Philip W Kantoff

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27 March 2020

Hebert Alberto Vargas

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Hebert Alberto Vargas

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27 March 2020

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Wassim Abida

1

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27 March 2020

Joshua Armenia

2

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27 March 2020

Anuradha Gopalan

3

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27 March 2020

Ryan Brennan

4

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27 March 2020

Michael Walsh

5

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27 March 2020

David Barron

6

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27 March 2020

Daniel Danila

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27 March 2020

Dana Rathkopf

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27 March 2020

Michael Morris

9

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27 March 2020

Susan Slovin

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27 March 2020

Brigit McLaughlin

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27 March 2020

Kristen Curtis

12

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27 March 2020

David M Hyman

13

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27 March 2020

Jeremy C Durack

14

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27 March 2020

Stephen B Solomon

15

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27 March 2020

Maria E Arcila

16

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27 March 2020

Ahmet Zehir

17

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27 March 2020

Aijazuddin Syed

18

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27 March 2020

Jianjiong Gao

19

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27 March 2020

Debyani Chakravarty

20

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27 March 2020

Mark E Robson

22

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27 March 2020

Vijai Joseph

23

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27 March 2020

Mark T A Donoghue

25

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27 March 2020

Adam A Abeshouse

26

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27 March 2020

Ritika Kundra

27

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27 March 2020

Zachary J Heins

28

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27 March 2020

Alexander V Penson

29

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27 March 2020

Christopher Harris

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27 March 2020

Barry S Taylor

31

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27 March 2020

Marc Ladanyi

32

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27 March 2020

Diana Mandelker

33

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27 March 2020

Liying Zhang

34

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27 March 2020

Victor E Reuter

35

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27 March 2020

David B Solit

37

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27 March 2020

Michael F Berger

38

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27 March 2020

Charles L Sawyers

39

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27 March 2020

Nikolaus Schultz

40

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27 March 2020

Howard I Scher

41

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publication date

31 May 2017

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27 March 2020

2017

1 reference

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27 March 2020

Integrative clinical genomics of advanced prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative genomic profiling of human prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mutational landscape of lethal castration-resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Molecular Taxonomy of Primary Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic basis for clinical response to CTLA-4 blockade in melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deciphering signatures of mutational processes operative in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OncoKB: A Precision Oncology Knowledge Base

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SPOP mutation leads to genomic instability in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of resistance to antiandrogen therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATM signalling and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signatures of mutational processes in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming mutation-based resistance to antiandrogens with rational drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical states in prostate cancer: toward a dynamic model of disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/28825054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1200/PO.17.00029

1 reference

Europe PubMed Central

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27 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28825054%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28825054%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

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