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ATM signalling and cancer

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scholarly article

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Europe PubMed Central

1 August 2017

ATM signalling and cancer (English)

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Europe PubMed Central

1 August 2017

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A Behrens

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C A Cremona

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Europe PubMed Central

1 August 2017

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publication date

15 July 2013

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Europe PubMed Central

1 August 2017

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Europe PubMed Central

1 August 2017

33

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Europe PubMed Central

1 August 2017

3351-3360

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Europe PubMed Central

1 August 2017

26

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Europe PubMed Central

1 August 2017

https://scigraph.springernature.com/pub.10.1038/onc.2013.275

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

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https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

GammaH2AX and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Multiple roles of ATM in monitoring and maintaining DNA integrity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM is required for efficient recombination between immunoglobulin switch regions

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The impact of heterochromatin on DSB repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATMIN defines an NBS1-independent pathway of ATM signalling

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https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Competition between NBS1 and ATMIN controls ATM signaling pathway choice

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https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM acts downstream of ATR in the DNA damage response signaling of bystander cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Analysis of protein dynamics at active, stalled, and collapsed replication forks.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM is required for the cellular response to thymidine induced replication fork stress.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

A two-step mechanism for TRF2-mediated chromosome-end protection

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Telomeres: protecting chromosomes against genome instability

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM activation by oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM protects against oxidative stress induced by oxidized low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM activation and signaling under hypoxic conditions.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Pseudo-DNA damage response in senescent cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Chemokine signaling via the CXCR2 receptor reinforces senescence

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Atm is a negative regulator of intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

A murine model of Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Loss of ATM kinase activity leads to embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Chfr and RNF8 synergistically regulate ATM activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Complementary functions of ATM and H2AX in development and suppression of genomic instability

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Asperlin induces G₂/M arrest through ROS generation and ATM pathway in human cervical carcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

WIP1 phosphatase at the crossroads of cancer and aging

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

An oncogene-induced DNA damage model for cancer development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Impaired insulin secretion in a mouse model of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM is a redox sensor linking genome stability and carbon metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Mitochondrial dysfunction in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Breast and other cancers in families with ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The MRE11 complex: starting from the ends.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Cancer risks and mortality in heterozygous ATM mutation carriers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Discovering moderate-risk breast cancer susceptibility genes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Rare variants in the ATM gene and risk of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM mutations in patients with hereditary pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

From pathogenesis to treatment of chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Patterns of somatic mutation in human cancer genomes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Somatic mutations affect key pathways in lung adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Recurrent R-spondin fusions in colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Whole-genome methylation analysis of benign and malignant colorectal tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA repair pathways as targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The combined status of ATM and p53 link tumor development with therapeutic response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Radiation-induced bystander signalling in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The role of ATM and 53BP1 as predictive markers in cervical cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Targeting hypoxic cells through the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Metformin and reduced risk of cancer in diabetic patients

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Diabetes and cancer: a consensus report.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Cancer research. Cancer prevention with a diabetes pill?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Autophosphorylation and ATM activation: additional sites add to the complexity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Cleavage and inactivation of ATM during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DOG 1.0: illustrator of protein domain structures

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

21 January 2018

DMAP1 is an essential regulator of ATM activity and function

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

31 March 2020

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

31 March 2020

An unusual form of diabetes mellitus in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

31 March 2020

Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

31 March 2020

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.275

31 March 2020

Identifiers

10.1038/ONC.2013.275

1 reference

Europe PubMed Central

1 August 2017

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0 references

1 reference

Europe PubMed Central

1 August 2017

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