(Q89568648)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference

0 references

2

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6 April 2020

Swee Hoe Ong

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

author name string

Meng Li

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Katarzyna Tilgner

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Hiroko Koike-Yusa

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Kosuke Yusa

6

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6 April 2020

language of work or name

English

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publication date

1 July 2018

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6 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

volume

24

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6 April 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

page(s)

489-502

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

6 April 2020

cites work

1 reference

12 December 2020

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

1 reference

12 December 2020

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

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12 December 2020

The art and design of genetic screens: yeast

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12 December 2020

The art and design of genetic screens: Drosophila melanogaster

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12 December 2020

The art and design of genetic screens: caenorhabditis elegans

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12 December 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

12 December 2020

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

1 reference

12 December 2020

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

1 reference

12 December 2020

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

1 reference

12 December 2020

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

1 reference

12 December 2020

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

1 reference

12 December 2020

The NuRD component Mbd3 is required for pluripotency of embryonic stem cells

1 reference

12 December 2020

Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal

1 reference

12 December 2020

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

1 reference

12 December 2020

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

12 December 2020

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.

1 reference

12 December 2020

Nanog safeguards pluripotency and mediates germline development

1 reference

12 December 2020

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

1 reference

12 December 2020

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells

1 reference

12 December 2020

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

1 reference

12 December 2020

The ground state of embryonic stem cell self-renewal

1 reference

12 December 2020

Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal

1 reference

12 December 2020

A PiggyBac-based recessive screening method to identify pluripotency regulators

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

1 reference

12 December 2020

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

1 reference

12 December 2020

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

1 reference

12 December 2020

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

1 reference

12 December 2020

Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells

1 reference

12 December 2020

The transcriptional and epigenomic foundations of ground state pluripotency.

1 reference

12 December 2020

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

1 reference

12 December 2020

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal

1 reference

12 December 2020

Naive pluripotency is associated with global DNA hypomethylation

1 reference

12 December 2020

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3

1 reference

12 December 2020

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog

1 reference

12 December 2020

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

1 reference

12 December 2020

Genetic screens in human cells using the CRISPR-Cas9 system

1 reference

12 December 2020

Genome-scale CRISPR-Cas9 knockout screening in human cells

1 reference

12 December 2020

Genetic exploration of the exit from self-renewal using haploid embryonic stem cells

1 reference

12 December 2020

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

1 reference

12 December 2020

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

1 reference

12 December 2020

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

1 reference

12 December 2020

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

1 reference

12 December 2020

Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency

1 reference

12 December 2020

Resetting transcription factor control circuitry toward ground-state pluripotency in human

1 reference

12 December 2020

Regulatory principles of pluripotency: from the ground state up.

1 reference

12 December 2020

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells

1 reference

12 December 2020

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

1 reference

12 December 2020

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

1 reference

12 December 2020

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

1 reference

12 December 2020

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

1 reference

12 December 2020

An updated evolutionary classification of CRISPR-Cas systems

1 reference

12 December 2020

Sestrin2 is a leucine sensor for the mTORC1 pathway

1 reference

12 December 2020

Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy

1 reference

12 December 2020

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

1 reference

12 December 2020

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

1 reference

12 December 2020

LIF signal in mouse embryonic stem cells

1 reference

12 December 2020

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

1 reference

12 December 2020

Inhibition of mTOR induces a paused pluripotent state

1 reference

12 December 2020

Formative pluripotency: the executive phase in a developmental continuum

1 reference

12 December 2020

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

1 reference

12 December 2020

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

1 reference

12 December 2020

PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.

1 reference

12 December 2020

mTOR Signaling in Growth, Metabolism, and Disease.

1 reference

12 December 2020

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

1 reference

12 December 2020

Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries

1 reference

12 December 2020

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

1 reference

12 December 2020

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

1 reference

12 December 2020

CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.

1 reference

12 December 2020

Defining essential genes for human pluripotent stem cells by CRISPR-Cas9 screening in haploid cells.

1 reference

12 December 2020

The CRISPR tool kit for genome editing and beyond.

1 reference

12 December 2020

10.1016/J.CELREP.2018.06.027

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29996108%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

29996108

1 reference