(Q89654680)

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α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

scientific article published on 24 February 2020

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Europe PubMed Central

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7 April 2020

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment (English)

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7 April 2020

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7 April 2020

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7 April 2020

Rolf Hilgenfeld

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7 April 2020

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Pieter Leyssen

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7 April 2020

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Eric J Snijder

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7 April 2020

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Yuri Kusov

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7 April 2020

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Kristina Lanko

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7 April 2020

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Daizong Lin

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7 April 2020

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Yong Nian

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7 April 2020

Albrecht von Brunn

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Albrecht von Brunn

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7 April 2020

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Linlin Zhang

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7 April 2020

Qingjun Ma

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7 April 2020

Jiang Wang

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7 April 2020

Adriaan de Wilde

11

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7 April 2020

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24 February 2020

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7 April 2020

Journal of Medicinal Chemistry

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7 April 2020

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold

1 reference

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Growth of human hepatoma cells lines with differentiated functions in chemically defined medium

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Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis

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Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides

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Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease

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Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

1 reference

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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers

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Identification of a new human coronavirus

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UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

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12 December 2020

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Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

1 reference

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pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

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Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex

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Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bio

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Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction

1 reference

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12 December 2020

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The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways

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A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

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Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #

1 reference

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12 December 2020

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Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

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12 December 2020

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GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication

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Molecular replacement with MOLREP

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Features and development of Coot

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REFMAC5 for the refinement of macromolecular crystal structures

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Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

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JLigand: a graphical tool for the CCP4 template-restraint library

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1 reference

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1 reference

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MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

1 reference

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1 reference

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12 December 2020

based on heuristic

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1 reference

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1 reference

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1 reference

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1 reference

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based on heuristic

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1 reference

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based on heuristic

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Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

1 reference

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1 reference

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1 reference

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Identifiers

10.1021/ACS.JMEDCHEM.9B01828

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7 April 2020

Dimensions Publication ID

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Dimensions COVID-19 publications, datasets and clinical trials

28 May 2020

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7 April 2020

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7 April 2020

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