(Q898669)

http://www.ebi.ac.uk/interpro/protein/Q92574

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

13 references

8 April 2019

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

The TSC1 gene product hamartin interacts with NADE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

protein N-terminus binding

IPI

3 references

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

Hsp70 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

Hsp90 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

GTPase activating protein binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

16 July 2018

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

biological process

rRNA export from nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

cerebral cortex development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

memory T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of protein kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

positive regulation of focal adhesion assembly

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of translation

1 reference

8 April 2019

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

hippocampus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of phosphoprotein phosphatase activity

1 reference

8 April 2019

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

potassium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

adaptive immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

protein heterooligomerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

cell projection organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

activation of GTPase activity

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of cell-matrix adhesion

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of cell size

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

1 reference

8 April 2019

Muscle atrophy in transgenic mice expressing a human TSC1 transgene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

cardiac muscle cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of translation

1 reference

8 April 2019

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of TOR signaling

4 references

16 July 2018

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574

16 July 2018

Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574

16 July 2018

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574

negative regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

positive regulation of macroautophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

regulation of stress fiber assembly

1 reference

8 April 2019

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

positive regulation of stress fiber assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of oxidative stress-induced neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

protein stabilization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

negative regulation of TOR signaling

5 references

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574