(Q90047400)

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Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer

scientific article published on 18 April 2019

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Europe PubMed Central

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10 April 2020

Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer (English)

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10 April 2020

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Stetson Thacker

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10 April 2020

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10 April 2020

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Charis Eng

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10 April 2020

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Iris Nira Smith

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10 April 2020

Marilyn Seyfi

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10 April 2020

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18 April 2019

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10 April 2020

American Journal of Human Genetics

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10 April 2020

104

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10 April 2020

5

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10 April 2020

861-878

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10 April 2020

describes a project that uses

1 reference

Europe PubMed Central

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

Localization of the gene for Cowden disease to chromosome 10q22–23

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

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inferred from PubMed ID database lookup

VMD: visual molecular dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

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inferred from PubMed ID database lookup

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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Germline mutations in PTEN are present in Bannayan-Zonana syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of side-chain clusters in protein structures by a graph spectral method.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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Relaxation kinetics and the glassiness of proteins: the case of bovine pancreatic trypsin inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN: one gene, many syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoscape: a software environment for integrated models of biomolecular interaction networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-world communication of residues and significance for protein dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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Network Analysis of Protein Structures Identifies Functional Residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-world network approach to identify key residues in protein-protein interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A network representation of protein structures: implications for protein stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a proteome-scale map of the human protein–protein interaction network

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GROMACS: fast, flexible, and free

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomeric protein structure networks: insights into protein-protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a distal mutation on active site chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residues crucial for maintaining short paths in network communication mediate signaling in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

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From molecular to biological structure and back

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Network analysis of protein dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contact rearrangements form coupled networks from local motions in allosteric proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into PTEN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A navigator for human genome epidemiology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tenets of PTEN tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric communication occurs via networks of tertiary and quaternary motions in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra and inter-molecular communications through protein structure network.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient non-native hydrogen bonds promote activation of a signaling protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Comparative Toxicogenomics Database: update 2011.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction energy based protein structure networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-genomic loss of PTEN function in cancer: not in my genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allo-network drugs: harnessing allostery in cellular networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lifetime cancer risks in individuals with germline PTEN mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of the protein phosphatase activity of PTEN

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topological analysis and interactive visualization of biological networks and protein structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein contact networks: an emerging paradigm in chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The topology and dynamics of protein complexes: insights from intra- molecular network theory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The underappreciated role of allostery in the cellular network.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allostery in disease and in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

INstruct: a database of high-quality 3D structurally resolved protein interactome networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depth: a web server to compute depth, cavity sizes, detect potential small-molecule ligand-binding cavities and predict the pKa of ionizable residues in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WebPSN: a web server for high-throughput investigation of structural communication in biomacromolecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A proteome-scale map of the human interactome network

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BioGRID interaction database: 2015 update

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane association of the PTEN tumor suppressor: neutron scattering and MD simulations reveal the structure of protein-membrane complexes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Mixed Protein Structure Network and Elastic Network Model Approach to Predict the Structural Communication in Biomolecular Systems: The PDZ2 Domain from Tyrosine Phosphatase 1E As a Case Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Database resources of the National Center for Biotechnology Information

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure network analysis to gain insights into GPCR function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamical network of residue-residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RING 2.0 web server for high quality residue interaction networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RCSB protein data bank: integrative view of protein, gene and 3D structural information

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A self-consistent structural perturbation approach for determining the magnitude and extent of allosteric coupling in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiplex assessment of protein variant abundance by massively parallel sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Network-based approach to prediction and population-based validation of in silico drug repurposing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biophysical simulations and structure-based modeling of residue interaction networks in the tumor suppressor proteins reveal functional role of cancer mutation hotspots in molecular communication

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Network-based prediction of drug combinations

1 reference

https://pubmed.ncbi.nlm.nih.gov/31006514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AJHG.2019.03.009

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Europe PubMed Central

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10 April 2020

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Europe PubMed Central

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10 April 2020

PubMed publication ID

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Europe PubMed Central

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10 April 2020

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