(Q30427743)

21 June 2017

The underappreciated role of allostery in the cellular network (English)

1 reference

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13 May 2020

3

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13 May 2020

1

Ruth Nussinov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

2

Chung-Jung Tsai

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

publication date

28 February 2013

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Annual Review of Biophysics

21 June 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

volume

42

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

page(s)

169-189

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Folding funnels, binding funnels, and protein function

13 May 2020

cites work

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12 December 2020

Folding and binding cascades: shifts in energy landscapes

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12 December 2020

Folding funnels and binding mechanisms

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12 December 2020

Folding and binding cascades: dynamic landscapes and population shifts

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12 December 2020

Structured disorder and conformational selection

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12 December 2020

Bistability in the JNK cascade

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12 December 2020

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

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12 December 2020

Testing a mathematical model of the yeast cell cycle

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12 December 2020

Network motifs in the transcriptional regulation network of Escherichia coli

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12 December 2020

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

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12 December 2020

MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

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12 December 2020

Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts

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12 December 2020

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.

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12 December 2020

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

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12 December 2020

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

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12 December 2020

Motifs, modules and games in bacteria

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12 December 2020

Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible

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12 December 2020

Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy

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12 December 2020

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

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12 December 2020

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors

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12 December 2020

Is allostery an intrinsic property of all dynamic proteins?

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12 December 2020

Genetic networks with canalyzing Boolean rules are always stable

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12 December 2020

Quantifying allosteric effects in proteins.

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12 December 2020

Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion

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12 December 2020

Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting

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12 December 2020

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12 December 2020

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

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12 December 2020

The Energy Landscapes and Motions of Proteins

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12 December 2020

Allosteric communication in dihydrofolate reductase: signaling network and pathways for closed to occluded transition and back

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12 December 2020

Visualizing spatially correlated dynamics that directs RNA conformational transitions

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12 December 2020

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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12 December 2020

Allostery: absence of a change in shape does not imply that allostery is not at play

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12 December 2020

Coupling between global dynamics and signal transduction pathways: a mechanism of allostery for chaperonin GroEL.

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12 December 2020

Energy flow in proteins

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12 December 2020

Eph, a protein family coming of age: more confusion, insight, or complexity?

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12 December 2020

Allostery and cooperativity revisited

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12 December 2020

Design of an optical switch for studying conformational dynamics in individual molecules of GroEL.

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12 December 2020

Allosteric regulation and catalysis emerge via a common route.

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12 December 2020

Light-activated DNA binding in a designed allosteric protein

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12 December 2020

Activation of tyrosine kinases by mutation of the gatekeeper threonine

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12 December 2020

Surface sites for engineering allosteric control in proteins

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12 December 2020

Small- and large-scale conformational changes of adenylate kinase: a molecular dynamics study of the subdomain motion and mechanics

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12 December 2020

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

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12 December 2020

Probing the flexibility of large conformational changes in protein structures through local perturbations

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12 December 2020

Frameworks for understanding long-range intra-protein communication

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12 December 2020

Perturbation waves in proteins and protein networks: applications of percolation and game theories in signaling and drug design.

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12 December 2020

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

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12 December 2020

Evidence for domain motion in proteins affecting global diffusion properties: a nuclear magnetic resonance study

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12 December 2020

Controlling proteins through molecular springs

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12 December 2020

Amplification of signaling via cellular allosteric relay and protein disorder

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12 December 2020

Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player

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12 December 2020

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade

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12 December 2020

The origin of allosteric functional modulation: multiple pre-existing pathways

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12 December 2020

'7TM receptor allostery: putting numbers to shapeshifting proteins

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12 December 2020

Protein-protein interaction networks: how can a hub protein bind so many different partners?

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12 December 2020

The role of dynamic conformational ensembles in biomolecular recognition

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12 December 2020

How do transcription factors select specific binding sites in the genome?

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12 December 2020

Mechanisms of transcription factor selectivity

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12 December 2020

Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases

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12 December 2020

Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?

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12 December 2020

A fluorescence anisotropy assay for the muscarinic M1 G-protein-coupled receptor

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12 December 2020

On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm

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12 December 2020

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

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12 December 2020

Post-translational modifications in signal integration

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12 December 2020

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

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12 December 2020

Cell signaling by receptor tyrosine kinases

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12 December 2020

Structure-switching biosensors: inspired by Nature.

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12 December 2020

Large-scale analysis of network bistability for human cancers

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12 December 2020

Diverse somatic mutation patterns and pathway alterations in human cancers

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12 December 2020

Protein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework.

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12 December 2020

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

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12 December 2020

Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance

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12 December 2020

Allostery and population shift in drug discovery

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12 December 2020

Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H

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12 December 2020

Protein dynamics and allostery: an NMR view

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12 December 2020

Mapping allostery through the covariance analysis of NMR chemical shifts

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12 December 2020

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

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12 December 2020

Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via dow

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12 December 2020

Dynamic protein–DNA recognition: beyond what can be seen

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12 December 2020

Transient protein-protein interactions.

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12 December 2020

Dynamic allostery: linkers are not merely flexible

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12 December 2020

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

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12 December 2020

How do dynamic cellular signals travel long distances?

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12 December 2020

Regulation of the catalytic activity of the EGF receptor.

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12 December 2020

Phosphorylation barcoding as a mechanism of directing GPCR signaling

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12 December 2020

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

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12 December 2020

Gene-specific transcription activation via long-range allosteric shape-shifting

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12 December 2020

Allo-network drugs: harnessing allostery in cellular networks

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12 December 2020

Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases

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12 December 2020

The powerstroke and camshaft of the RIG-I antiviral RNA detection machine

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12 December 2020

Atomistic kinetic model for population shift and allostery in biomolecules.

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12 December 2020

Molecular dynamics simulations and drug discovery

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12 December 2020

Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics

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12 December 2020

Mechanisms of allosteric gene regulation by NMR quantification of microsecond-millisecond protein dynamics

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12 December 2020

Allosteric modulators can restore function in an amino acid neurotransmitter receptor by slightly altering intra-molecular communication pathways

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12 December 2020

Promiscuity in protein-RNA interactions: conformational ensembles facilitate molecular recognition in the spliceosome: conformational diversity in U2AF⁶⁵ facilitates binding to diverse RNA sequences.

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12 December 2020

Intrinsic disorder: signaling via highly specific but short-lived association

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12 December 2020

Queueing up for enzymatic processing: correlated signaling through coupled degradation

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12 December 2020

Kinetic rate constant prediction supports the conformational selection mechanism of protein binding

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12 December 2020

Protein dynamics and conformational selection in bidirectional signal transduction

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12 December 2020

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

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12 December 2020

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

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12 December 2020

The condensed chromatin fiber: an allosteric chemo-mechanical machine for signal transduction and genome processing

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12 December 2020

The role of conserved waters in conformational transitions of Q61H K-ras

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12 December 2020

IκB kinase regulation of the TPL-2/ERK MAPK pathway

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12 December 2020

Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB

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12 December 2020

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

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12 December 2020

Allosteric inhibition of individual enzyme molecules trapped in lipid vesicles.

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12 December 2020

Biomolecular simulation: a computational microscope for molecular biology

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12 December 2020

Somatic STAT3 mutations in large granular lymphocytic leukemia

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12 December 2020

NFAT control of innate immunity

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12 December 2020

Molecular signaling network complexity is correlated with cancer patient survivability

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12 December 2020

The Hippo signaling pathway and stem cell biology

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12 December 2020

Wnt/β-catenin signaling and disease

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12 December 2020

The B-cell receptor signaling pathway as a therapeutic target in CLL.

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12 December 2020

Evolution of two-component signal transduction systems

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12 December 2020

Dimerizer-mediated regulation of gene expression in vivo

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12 December 2020

NF-κB signaling pathways: role in nervous system physiology and pathology

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12 December 2020

Lymphotoxin-beta receptor expression and its related signaling pathways govern dendritic cell homeostasis and function

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12 December 2020

WNT secretion and signalling in human disease.

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12 December 2020

Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling

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12 December 2020

Structural basis for intersubunit signaling in a protein disaggregating machine

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12 December 2020

Allosteric post-translational modification codes

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12 December 2020

Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

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12 December 2020

From Levinthal to pathways to funnels

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12 December 2020

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

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12 December 2020

Hydrophobic folding units at protein-protein interfaces: implications to protein folding and to protein-protein association

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12 December 2020

How responses get more switch-like as you move down a protein kinase cascade.

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12 December 2020

Protein folding in the landscape perspective: chevron plots and non-Arrhenius kinetics

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12 December 2020

The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes

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12 December 2020

10.1146/ANNUREV-BIOPHYS-083012-130257

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6407633&resulttype=core&format=json