(Q37995683)

26 August 2017

title

IκB kinase regulation of the TPL-2/ERK MAPK pathway (English)

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26 August 2017

Michael Sadowski

3

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author name string

Thorsten Gantke

series ordinal

1

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26 August 2017

Srividya Sriskantharajah

series ordinal

2

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26 August 2017

Steven C Ley

series ordinal

4

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26 August 2017

publication date

1 March 2012

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26 August 2017

published in

Immunological Reviews

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26 August 2017

volume

246

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26 August 2017

issue

1

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26 August 2017

page(s)

168-182

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Toll-like receptors and innate immunity

26 August 2017

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

21 January 2018

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21 January 2018

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21 January 2018

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ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking

21 January 2018

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Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.

21 January 2018

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

21 January 2018

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Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

21 January 2018

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Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii

21 January 2018

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Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function

21 January 2018

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21 January 2018

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21 January 2018

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Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

21 January 2018

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Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

21 January 2018

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The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity

21 January 2018

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Tpl2 kinase signal transduction in inflammation and cancer.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Involvement of Cot activity in the proliferation of ALCL lymphoma cells.

21 January 2018

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 January 2018

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21 January 2018

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Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis

21 January 2018

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Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

21 January 2018

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Oncogenic activation of NF-kappaB.

21 January 2018

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A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression

21 January 2018

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Immunity, Inflammation, and Cancer

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

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21 January 2018

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p50 Nuclear Factor- B Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance

21 January 2018

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Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.

21 January 2018

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

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Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105.

21 January 2018

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Cot/Tpl-2 protein kinase as a target for the treatment of inflammatory disease

21 January 2018

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21 January 2018

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

21 January 2018

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Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

21 January 2018

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Innate immune recognition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.

21 January 2018

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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

NF-κB and the link between inflammation and cancer

21 January 2018

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Structural Comparison of Human Mammalian Ste20-Like Kinases

21 January 2018

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Basic local alignment search tool

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

COBALT: constraint-based alignment tool for multiple protein sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

The phosphoproteome of toll-like receptor-activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01104.X

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

21 January 2018

1 reference

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10.1111/J.1600-065X.2012.01104.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference